Audiologic Monitoring of Multi-Drug Resistant Tuberculosis Patient on Aminoglycoside Treatment with Long Term Follow -Up
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Objective: Early identification of ototoxic hearing loss provides physicians the opportunity to adjust the therapeutic treatment in order to minimize or prevent hearing loss requiring rehabilitation, depending on a patient's overall treatment picture Method: About fifty newly patiens of MDR-TB who are to be treated by second line drug will be enrolled to the purposed study.-Hearing status of these patient would we advised to undergo evaluation of their audiometry status before the commencement of the treatment.The auditory status evalution comprising of tuning fork test pure tone audimatory would be performed at the interval of 1month. Results:Hearing loss of 15 decibels (dB) at two or more frequencies, or at least 20 dB hearing loss at at least one frequency, was found in 18% of our total population treated with aminoglycosides (amikacin, kanamycin and/or streptomycin). In the group treated with kanamycin this percentage was 15.6. None of the factors sex, age, treatment duration, total aminoglycoside doses or first serum creatinine concentration, was found to be associated with hearing loss. Conculsion:Aminoglycosides used in MDR-TB patients may result in irreversible hearing loss involving higher frequencies and can become a hearing handicap as speech frequencies are also involved in some of the patients thus underlining the need for regular audiologic evaluation in patients of MDR-TB during the treatment
Authors and Affiliations
Dr Dharmendra kumar, Dr S. P Singh, Dr VarunKumar Thakur
Keywords
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- EP ID EP243680
- DOI 10.9790/0853-1610061015
- Views 68
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