AUGMENTING POTENTIAL ANTIFUNGAL ACTIVITY OF GANDHAKA RASAYANA (A SIDDHA COMPOUND) USING GREEN SYNTHESIZED SILVER NANOPARTICLES FROM COUROUPITA GUIANENSIS LEAF EXTRACT AGAINST SELECTED PATHOGENIC STRAINS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 6
Abstract
In the present study, augmented antifungal activity of Gandhaka Rasayana in the presence of biosynthesized silver nanoparticles against selected Candida spp. has been demonstrated. Silver nanoparticles were biologically synthesized from the leaf extract of Couroupita guianensis. The stable silver nanoparticles were characterized by means of UV-Vis spectrophotometer, XRD, TEM, EDX and FTIR; the nanoparticles exhibited maximum absorbance at 415 nm in the UV spectrum. The presence of proteins and functional group was identified by FTIR. TEM micrograph revealed the formation of polydispersed nanoparticles and the presence of elemental silver was confirmed by EDS analysis. The antifungal activity of Gandhaka Rasayana drastically increased in the presence of lower concentration of biologically synthesized silver nanoparticles. This would be helpful in reducing the side effects caused by the excess use of the drug.
Authors and Affiliations
Manjumeena Rajarathinam, M. Girilal, Magesh peter, P. T. Kalaichelvan
Keywords
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