Autoimmune Diseases and Their Prevalence in Females: A Review
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 7
Abstract
Autoimmune diseases affect approximately 8% of the population, 78% of which show female preponderance. The reasons for the high prevalence in women are unknown, but circumstantial evidence links autoimmune diseases with preceding infections. One of the most putative mechanism is related to sex chromosomes, based upon the recent observation that women with autoimmune diseases manifest a higher rate of circulating leukocytes with a single X chromosomes leading to X Inactivation. One of the other factors are sex hormones. Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune disease in women.
Authors and Affiliations
Dr. Shriya Khera
Keywords
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