Autologous hematopoietic cell transplantation in adult patients with germ cell tumors and soft tissue sarcomas
Journal Title: Współczesna Onkologia - Year 2006, Vol 10, Issue 1
Abstract
The prognosis of recurrent or refractory solid tumors is dismal and few patients have experienced prolonged survival. For patients with metastatic neuroblastoma or Ewing`s sarcoma treated conventionally, the prognosis for disease-free survival 3 years from the diagnosis remains < 20 per cent. Conventional-dose salvage approaches to patients with poor risk, recurrent or refractory germ cell tumors lead to remission in 30-60% of patients, but only 20% gain long-term survival. High dose chemotherapy has been considered an attractive approach in the treatment of patients with chemo- or radiosensitive malignancies for the late eighties. Transplant numbers increased massively for several years. A change in attitude occured in 1997. Doubts about initial reports, failures of prospective controlled studies brought about this change. Phase II trials indicate a 10 proc. improvement in survival with early intensification of salvage treatment using high dose chemotherapy in patients suffering from germ cell tumors. However, no advantage was observed according to the results of a large randomized trial. We are still waiting for results of three prospective, randomized trials evaluating the role of autologous stem cell transplantation in a first line setting. For young adults with neuroblastoma, Ewing`s sarcoma or soft tissue sarcomas the same approach as in paediatric patients can be used, and prospective phase III trials suggest an advantage of high dose chemotherapy in patients with neuroblastoma. Data from many transplant centers at least suggest that neuroblastoma and Ewing’s sarcoma and probably soft tissue sarcomas are
Authors and Affiliations
Piotr Rzepecki, Tomasz Sarosiek, Cezary Szczylik
Acute phase proteins in patients with head and neck cancer
The determination of acute phase proteins such as albumin, prealbumin, alpha-1 acid glycoprotein, alpha-1 antitrypsin, transferrin, C-reactive protein and also calculation of coefficients such as CSI, CRP/PRE and PINI...
A novel therapy with zoledronic acid od bone metastasis in advanced prostate cancer reflecting molecular investigations
Prostate cancer continues to represent a major therapeutic challenge. There is still observed a large number of patients worldwide. This malignancy is mainly diagnosed in industrialized countries. Dietary factors, life...
The role of endocrine therapy in adjuvant management for premenopausal breast cancer patients
The efficacy of adjuvant treatment in some cases of early breast cancer is unquestionable. In 1998, the first report about the role of adjuvant treatment was published. Opinion leaders, such as the International Expert...
Centralny ziarniniak olbrzymiokomórkowy żuchwy o różnym przebiegu klinicznym – przegląd piśmiennictwa i własne obserwacje
Centralny ziarniniak olbrzymiokomórkowy (Central Giant Cell Granuloma, CGCG) należy – wg klasyfikacji WHO – do zmian guzopodobnych. Jest to rzadko występująca zmiana odczynowa w obrębie części twarzowej czaszki (7%), z...
Coexistence of prostate cancer and disseminated hepatocellular carcinoma - a case report
A case of a 64-year old male with multiple bone metastases is presented. Because of elevated serum PSA level an oligobiopsy of the prostate was performed and a single focus of grade 1 prostatic cancer was found. The pati...