Autonomic Function Testing and Ganglioside Antibody Testing In Correlation with Short Term Outcome in Guillain – Barre Syndrome
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Introduction: Guillain–Barré syndrome, which is characterized by acute are flexic paralysis with albuminocytologic dissociationis currently the most frequent cause of acuteflaccid paralysis worldwide and constitutes one of the serious emergencies inneurology.Autonomic dysfunction (AD) is a common and important complication in Guillain-Barré syndrome and may be the cause of significant morbidity or death.We conducted the present study with an aim to include antibody testing and autonomic function testing in GBS patients and see if they carried any clinical significance. Aims and Objectives of the Study: 1. To study association between antiganglioside antibodies and outcome inGuillain-Barre Syndrome.2. To study autonomic involvement and antiganglioside antibodies in different subtypes of Guillain-Barre Syndrome. Methods: A sample of 50 subjects fulfilling the inclusion and exclusion criteria were taken and different types of Guillain Barre Syndrome were analysed. Autonomic functioning and Anti-ganglioside antibodies were obtained and their association was assessed. Results: Autonomic dysfunction was seen in 34(68%) patients.IgG antibodies are positive in only 14% of the cases and 44% of AMAN patients.There was no relation between the antiganglioside antibodies and outcome of GBS. Conclusions: Antiganglioside antibodies showed significant association with axonal variants but they didn’t show any correlation with their outcome.GT1b antibody was the commonest antiganglioside antibody associated with the axonal variant.
Authors and Affiliations
Dr. A. Gopi Krishna, Dr. Kanduri Soumya, Dr. G. Butchi Raju, Dr. S. Gopi, Dr. T. Sateesh Kumar, Dr. U. Aruna Kumari
Keywords
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- EP ID EP574560
- DOI 10.9790/0853-1804140107.
- Views 77
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