Bacterial interference with host epithelial junctional complexes: Probiotic bacteria vs. A/E lesion-forming Escherichia coli
Journal Title: Journal of BioScience and Biotechnology - Year 2012, Vol 1, Issue 2
Abstract
During colonization, enteropathogenic (EPEC) and enterohaemorrhagic (EHEC) Escherichia coli are capable to manipulate host cytoskeleton and colonize gut epithelia by a specific mode of attachment known as the attaching and effacing lesion (A/E lesion). While actin rearrangements during A/E lesion formation have been extensively investigated, the possible alterations of other cytoskeletal elements like those comprising the intercellular junctional complexes (JC) of polarized cells during infection have only lately attracted attention. The present mini-review addresses the opposite effects of two groups of bacteria, A/E lesion-forming pathogenic E. coli and probiotic bacterial strains, on JC. JC are important in maintaining gut barrier functions. EPEC and EHEC can disrupt JC which as a consequence leads to reduction in the transepitelial electrical resistance (TER) and an increase of the permeability to macromolecules. Probiotic bacteria on the other hand stabilize JC thus increasing TER and reducing permeability to macromolecular markers. Probiotic strains can protect JC integrity of polarized cells from the damage caused by EPEC or EHEC. Together with the promise of these results, of concern is the fact that the outcome of the studies can differ dependent on experimental protocols. Studies with living bacteria and different strain combinations have also put forward strain specific effects. Therefore, an important practical item for future studies is the identification of the molecules synthesized by probiotic bacteria that may be active on JC stability.
Authors and Affiliations
Tania Topouzova-Hristova, Elena Stephanova, Stoyanka Stoitsova
Keywords
Related Articles
- EP ID EP98149
- DOI -
- Views 65
- Downloads 0
Physiological damage in Algerian mouse Mus spretus (Rodentia: Muridae) exposed to crude oil
Small mammals have been used to predict ecotoxicological damage caused by metals in field studies and laboratory exposure. In natural ecosystems, rodents play an important role either as seed dispersers or food providers...
Changes in composition and structure of breeding bird communities due to successive changes in ecosystems
Successive changes in ecosystems are due to natural and/or anthropogenic influences. These changes influence species richness and structure of phyto- and zoocenoses. Birds represent a good indicator for changes of...
Fluorescence study on ligand induced conformational changes of glutamine synthetase from Bacillus brevis Bb G1 under sporulating conditions
Glutamine synthetase, an important enzyme of nitrogen metabolism, was purified under sporulating conditions (GSala). The effect of ligands on the tryptophan fluorescence of the purified enzyme GSala was investigate...
The effects of different sizes of insoluble grit on growth performance and carcass traits in broiler chickens
The present study was conducted to investigate the effects of different sizes of insoluble grit on growth performance and carcass traits in broiler chickens. A total of 200 broilers (Ross 308), 10 days old, were randomly...
Study of root distribution of Macaranga tanarius (L.) Müll. Arg. (Parasol leaf tree) on East-West highway slope, Malaysia
Vegetation influences the stability of slope by both hydrological events and mechanical reinforcement of the soil. The magnitude of such effects is subject to the root system growth, which in turn is a purpose of the gen...