Bacterial profile and antibiotic susceptibility in chronic obstructive pulmonary disease patients with acute exacerbation: A cross sectional study in a tertiary care hospital
Journal Title: Indian Journal of Microbiology Research - Year 2016, Vol 3, Issue 3
Abstract
Background: The course of Chronic Obstructive Pulmonary Disease (COPD) is characterized by intermittent exacerbations of the disease. The bacterial pathogens contribute a lot in mucus secretions and the acute exacerbations. This study was conducted to determine the bacterial profile and antibiotic susceptibility in COPD patients visiting a tertiary care hospital. Methods: A cross sectional study was conducted in a tertiary care hospital over a period of 15 months. The sputum samples were collected from COPD patients admitted in the Pulmonology department. Purulent sputum samples were subjected to Gram staining followed by culture and antibiotic susceptibility testing according to the standard guidelines. Result: Sputum samples from 477 COPD patients (50-85 years) were collected and significant isolates were obtained from 106 sputum samples (94 males and 14 females). The isolates were Streptococcus pneumoniae-22%, Mucoid Pseudomonas aeruginosa-17%, Moraxella catarrhalis-13%, Haemophilus influenzae- 13%, followed by Klebsiella pneumoniae- 11%, Non-mucoid Pseudomonas aeruginosa -8%, Stenotrophomonas maltophilia- 7%, Acinetobacter baumannii- 3% and Staphylococcus aureus and Group C Streptococci 1% each. Only 2 isolates of S. pneumoniae showed penicillin and erythromycin resistance. The mucoid P.aeruginosa, the 2nd most prevalent, was susceptible to ciprofloxacin, ceftazidime and gentamicin. M. catarrhalis and H. influenzae were susceptible to amoxicillin- clavulanic acid and azithromycin. K. pneumoniae and Non-mucoid P. aeruginosa showed variable susceptibility. Isolates of S. maltophilia were susceptible to co-trimoxazole. Conclusion: Susceptible strains of mucoid P. aeruginosa and S. maltophilia have also been isolated as potential pathogens. They were susceptible to fluoroquinolones and S. tenotrophomonas maltophilia was susceptible to co-trimoxazole also.
Authors and Affiliations
Kundoly Velayudhan Suseela, Davis Rennis, Santosh Patil, Aiswariya Alex
Keywords
Related Articles
- EP ID EP241272
- DOI -
- Views 79
- Downloads 0
Scrub typhus & Dengue Co-infection among patients attending a tertiary care hospital at Puducherry
Background: Scrub typhus & Dengue fever are being increasingly reported from tropical countries including India. Both of them are vector borne with a peak incidence during post monsoon period, although prevalent througho...
Correlation of VITEK -2 and conventional tests in identification of Non Fermenting Gram Negative Bacilli in a Tertiary Care Hospital
Introduction: The non-fermentative Gram negative bacilli (NFGNB) are a group of aerobic, non-spore forming, Gram negative bacilli that either do not utilize carbohydrates as a source of energy or degrade them through met...
Bacteriological study on mechanically ventilated patients and incidence of ventilator associated pneumonia
Aim: To determine the bacteriology of mechanically ventilated patients and to know about incidence of ventilator associated pneumonia in a tertiary care hospital. Ventilator associated pneumonia is the commonest hospital...
Emergence of Extensively drug-resistant Acinetobacter spp in a tertiary care centre of Hyderabad, Telangana state
Introduction: Acinetobacter spp., a gram negative coccobacillus, were considered to be opportunistic pathogen till their role in hospital acquired infections was described. It has been declared as one of the ESKAPE patho...
Modified Widal test using 2-mercaptoethanol for detecting anti-salmonella IgM in febrile patients
Introduction: Despite limitations, the Widal test is widely used in resource-constrained settings because it is fast, inexpensive and user-friendly. Therefore, efforts continue to improve its diagnostic utility. Aims: Us...