Bacteriological profile and antibiotic sensitivity pattern of neonatal sepsis in a tertiary care hospital of northern India
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2016, Vol 3, Issue 11
Abstract
Introduction: Neonatal sepsis is the single most important cause of neonatal deaths in the community. Objectives: To identify the common bacterial pathogens associated with neonatal sepsis and to identify their antibiotic sensitivity pattern. Material and Methods: During the study period, all the neonates admitted in neonatology ward were screened for sepsis by physical examination and clinical features. All infants satisfying the criteria for sepsis were subjected for blood culture. Growths, if any were noted and standard antibiotic sensitivity was performed by the Kirby-Bauer disc diffusion method as per the CLSI recommendations. Results: Out of 2520 neonates admitted in neonatal intensive care unit over a period of one year, 89 neonates were diagnosed as having septicemia. Incidence of sepsis in our hospital was 35.3/1000 neonatal admissions. Out of 89 clinically suspected and positive screening test cases of neonatal sepsis, 48.31% were culture proven cases of neonatal sepsis. Klebsiella was found to be the predominant pathogen (34.88%) of the culture positive cases followed by staphylococcus aureus in 32.5% and E. coli in 9.30% cases. Majority of the organisms were resistant to commonly used antibiotics like ampicillin, cloxacillin and ceftriaxone. Aminoglycosides were relatively more effective treatment modalities against gram negative organisms while vancomycin was the most sensitive drug against Staphylococcus aureus. Conclusions: In view of growing bacterial resistance to commonly used antibiotics, knowledge of bacterial pathogens prevalent in NICU and their antimicrobial susceptibility pattern will help the clinician to select appropriate antibiotics for treatment of suspected neonatal sepsis cases.
Authors and Affiliations
Minakshi Bhat, G. S. Saini
Keywords
Related Articles
- EP ID EP227369
- DOI 10.17511
- Views 126
- Downloads 0
To assess iron deficiency anaemia in patients with cyanotic heart disease compared to general population
Objective: Congenital heart disease has an overall incidence of 8 per 1000 live births. It can be grouped into acyanotic congenital heart diseases (without a shunt or with a left to right shunt) and cyanotic congenital h...
Profile of children admitted with seizures to a tertiary care rural hospital in Mandya district
Background: Seizures is one of the common causes of pediatric admissions to hospitals with significant mortality and morbidity. As there is limited data on profile regarding acute seizures episodes form the developing co...
Effect of L- Carnosine, DHA and vitamin D3 on children with down’s syndrome- a pilot study on Indian population
Background: Down syndrome (DS) is one of the leading genetic causes of intellectual disability (ID) accounting 15– 20% of ID population across the world. Early intervention is the potential treatment; alternative therapi...
A study of the disability impact among parents of mentally challenged children
Back ground: The child with mental retardation has special needs in addition to the regular needs of all children, and parents can find themselves over whelmed by various medical, care giving, financial and educational r...
Atypical Presentation of Celiac Disease: A Case Report
Celiac disease is a chronic inflammatory immune-mediated condition associated with small intestinal injury triggered by gluten present in wheat, barley and rye, leading to malabsorption of different nutrients. Usually it...