Basic Haematological Scoring System-Is it the most Accurate Neonatal Sepsis Predictor?
Journal Title: National Journal of Laboratory Medicine - Year 2018, Vol 7, Issue 3
Abstract
Introduction: Sepsis in neonates contributes for approximately 15% of the neonatal mortality in India. Even though a positive blood culture is pertinent for diagnosis, the technique is time consuming and is positive in only 10-40% cases. Aim: The purpose of this study was to assess the effectiveness of haematological criteria studied by Rodwell RL et al., in 1988 in early prediction of neonatal sepsis and to correlate the score obtained with other ancillary tests like CRP, micro-ESR, Procalcitonin and culture. Materials and Methods: In the present study, blood samples of 450 neonates with clinical suspicion of sepsis were studied for one and half years. Leishman stained peripheral smear of these neonates was evaluated and scored on a scale of 7 based on the haematological parameters of Rodwell’ s criteria. An impression of unlikely, possible and very likely of sepsis was assigned to scores of < 2, 3 or 4 and > 5 out of 7 respectively. Results: Out of the total 450 cases, 120 (27%) cases were sepsis proven showing high Rodwell’s score and culture positivity. In these cases the performance of HSS scoring system was separately evaluated. Of the individual parameters the absolute neutrophilia count and increased immature neutrophil count had highest specificity of 91% and 92% respectively. The other parameters like, Immature: Total ratio, degenerative changes and thrombocytopenia were statistically significant with p-value <0.005. Conclusion: Haematological scoring system is rapid, simple, inexpensive and reliable test in the early diagnosis of neonatal sepsis against the gold standard culture in differentiating infected from non-infected neonates.
Authors and Affiliations
Tushar Priyanka, Dr. Hemalata
Keywords
Related Articles
- EP ID EP534990
- DOI 10.7860/NJLM/2018/36889:2308
- Views 132
- Downloads 0
Prevalence of Group A Streptococcal Carriage Rate in Asymptomatic Children
ABSTRACT Introduction: Streptococcus pyogenes is a Gram positive cocci causing respiratory infections commonly in children. Throat carriers are children in whom the organism is isolated from throat swab specimens in the...
Serum Calcium and Magnesium levels in Pre-eclampsia
Introduction: Pre-eclampsia (PE) is a disorder of pregnancy characterised by hypertension with proteinuria after 20 weeks of pregnancy in previously normotensive and non-proteinuric patients which may progress to seizure...
Chryseobacterium indologenes Bacteraemia in a Man with Oesophageal Cancer: A Case Report
Chryseobacterium indologenes is a rare pathogen of the humans and is normally found in the environment in soil, plants and foodstuffs. Infections caused by C. indologenes have been reported as a cause of serious infectio...
Sertaconazole Nitrate 2% Cream for the Treatment of Tinea pedis
Introduction: Tinea pedis is a superficial fungal infection of the skin of feet caused by dermatophytes and characterized by erythema, desquamation, itching, vesicles and pustules in the interdigital or subdigital area,...
Hepcidin- A Burgeoning Biomarker
The discovery of hepcidin has triggered a virtual ignition of studies on iron metabolism and related disorders. The peptide hormone hepcidin is a key homeostatic regulator of iron metabolism. The synthesis of hepcidin is...