BEHAVIOUR OF ANAPLASTIC THYROID CARCINOMA IN TERTIARY CARE CENTRE, SOUTH INDIA.
Journal Title: IJSR-International Journal Of Scientific Research - Year 2018, Vol 7, Issue 11
Abstract
INTRODUCTION: Anaplastic thyroid cancer (ATC) is one of the most aggressive solid tumors to affect humans, with a median survival on the order of 3 to 5 months following diagnosis [1]. Recent advances in understanding the genetic and molecular pathogenesis of ATC hold promise for targeted therapy for this disease. METHODS: This retrospective study was conducted for 7 years from 2011 to 2018, included patients who were admitted in the endocrine surgery department in the tertiary hospital with thyroid malignancies. The clinical, operative, cytological, and histological data were tabulated and statistically analyzed. RESULTS: Of the 386 patients analyzed, 350 patients (91.57%) were females and 36 patients were males (9%) (P < 0.001) which shows high significant difference between genders at 0.1% level. Final Histopathology showed papillary thyroid carcinoma in 340 patients, poorly differentiated thyroid carcinoma in 8 patients, anaplastic thyroid carcinoma in 18 patients. Out of 18 patients with anaplastic thyroid carcinoma 8 patients presented with mild dyspnea, 2 patients had dysphagia and 10 patients suffered from hoarseness of voice. The mean patients age were 45 years. 12 patients had intra thyroid tumour, 4 patients had invasion to the strep muscles, 2 patients had adhered to trachea. Overall cause specific mortality rate was 60% at 6 months and 40 % at 12 months. CONCLUSION: The overall prognosis of ATC continues to be poor with the 5 year survival from 5.6 to 11.4% . Age is the most important factor in the patients with ATC.
Authors and Affiliations
Dr. S. Zahir Hussain, Dr. M. P. Kumaran
Keywords
Related Articles
- EP ID EP510392
- DOI -
- Views 73
- Downloads 0
A PROSPECTIVE STUDY OF SERUM LIPIDS PROFILE IN GUWAHATI CITY
Progress in lipid modification therapy has resulted in a relative risk reduction of one-third in major vascular events but has not reduced cardiovascular disease mortality significantly. The study was conducted to invest...
ASSESSMENT OF KNOWLEDGE AND PRACTICE ABOUT BIOMEDICAL WASTE MANAGEMENT AND ASSOCIATED FACTORS AMONG HEALTH CARE PERSONNEL IN A PUBLIC HOSPITAL OF RAJASTHAN
Background: For proper disposal of biomedical waste, introduction of laws is only not sufficient but awareness among health care personnel and effective enforcement of existing BMW guidelines have primary importance. Lac...
A CLINICAL, HISTOPATHOLOGICAL AND DIRECT IMMUNOFLUORESCENCE CORRELATION OF AUTOIMMUNE BULLOUS DISORDERS
Background: Autoimmune vesiculobullous disorders are group of blistering dermatoses in which pathogenic autoantibodies are present against various antigens against adhesion molecules in epidermis and dermo-epidermal junc...
HISTOPATHOLOGICAL SPECTRUM OF ORAL LESIONS IN A TERTIARY CARE HOSPITAL
Oral cavity is the site of several tumour and tumour like lesions . Aim of this study is to study the spectrum of oral cavity lesion. It is a hospital based retrospective study conducted for a period of 1 year from April...
A COMPARATIVE STUDY OF CENTCHROMAN VS DANAZOL VS EVENING PRIMROSE OIL IN THE MANAGEMENT OF MASTALGIA AND FIBROADENOMA
We conducted an prospective nonrandomized interventional study to compare the efficacy of a newer therapeutic agent Centchroman with established therapeutic agents Danazol and Evening Primrose Oil ( EPO ) in the treatmen...