Behaviour of Uric Acid, the Final Metabolic Product of Purines, in Stored CPDA (Citrate-Phosphate-Dextrose-Adenine) Whole Blood Units
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 8
Abstract
Abstract:Some nutrient media like CPDA (Citrate -phosphate-dextrose-adenine), for blood storage, contain adenine for improved storage of erythrocytes, but the dynamics of its final catabolic product i.e. uric acid (UA) has not been studied in detail. Sixteen CPDA-1 whole blood bags were used for baseline and subsequent weekly determination of UA, Potassium (K), Sodium (Na) and Albumin (Alb) in the extracellular fluid and Hemoglobin (WB Hb) in whole blood during the initial four weeks of storage using automated machines. Unidirectional changes were seen in concentrations of K (increase; ANOVA p< 0.0001), Na (decrease; ANOVA p< 0.0001) whereas no change was seen in WB Hb (ANOVA p= 0.99) and a tri-modal pattern (increase-decrease-increase) was observed for UA (ANOVA p < 0.0001) and Alb (ANOVA p= 0.01) across the storage period. The changes in K and UA might prove useful in conferming the age of blood bags. Keywords:CPDA, Uric acid, Potassium, Sodium, Albumin, Hemoglobin
Authors and Affiliations
Simant Baliarsingh
Keywords
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