Beneficial Effect of Zinc on diabetes induced kidney damage and liver stress oxidative in rats
Journal Title: JOURNAL OF ADVANCES IN BIOLOGY - Year 2017, Vol 10, Issue 1
Abstract
The present study was designed to investigate the effects of Zn supplementation on kikney function and liver oxidative stress in Alloxan diabetic rats. Male albino Wistar rats were randomly divided into 4 groups (n=10): Control, Non Diabetic + zinc, Diabetic and Diabetic + Zinc. Diabetes was induced by alloxan (150 mg/kg). Zinc (231 mg/kg feed) as ZnSO4 7H2O was added to the feed of the animals in the zinc groups for 21 days. Alloxan Diabetes caused a significant decrease in body weight gain, serum and tissue zinc, serum protein concentrations, liver GSH, GPx and GST activities .In contrast, it led to an augmentation in urea, creatinine, uric acid and MDA in rats. Zinc supplementation in the diet for diabetic rats ensured a partial correction of the previous parameters. In conclusion, this study indicated that zinc act as powerful antioxidants which may exercise adverse effect against severity and complication of diabetes.
Authors and Affiliations
Samir Derouiche, Djermoune Manel, Abbas Kawther
Keywords
Related Articles
- EP ID EP654551
- DOI 10.24297/jab.v10i1.6022
- Views 165
- Downloads 0
The effect of jujube oil on some biological activities of Culex pipiens mosquito
Synthetic insecticides are quick, effective and most popular methods of pest control. But because of their unfavorable effects on environment and non-target organisms, there is a growing need to find new, safe effective...
Home gardens in the maintenance of biological diversity
Home garden is an integrated system which comprises different things in its small area that produces a variety of foods and agricultural products including staple crops, vegetables, fruits, medicinal plants and so on. In...
Purification and Characterization of Pectinase from Bacillus licheniformis obtained from a Cassava Waste Dump
This study investigated the properties of pectinase from Bacillus licheniformis. The pectinase secreted by the microorganism was purified using ion exchange and gel filtration chromatography on DEAE-Sephadex and Sephadex...
Evidence of the association of begomovirus and its betasatellite with the yellow vein disease of an ornamental plant Calendula officinalis (pot marigold) in Rajasthan, India: Molecular, Sequence and Recombination analysis
Begomoviruses are major threats for various crops species throughout the globe, particularly in tropical and sub-tropical regions. Mutation, pseudorecombination and recombination are driving forces for the emergence and...
Isolation and Identification of Escherichia coli from various foodstuffs and their Resistance against clinically significant antibiotics
A total of fifty-seven ready-to-eat food samples were collected from different locations of NCR, India to explore the prevalence of Escherichia coli in some commonly offered foodstuffs and to assess the antibiotic resist...