BENEFICIAL ROLE OF HERBAL HEPATOPROTECTANTS: A NOVEL APPROACH TO PREVENT HEPATOTOXICITY DUE TO ANTITUBERCULOSIS TREATMENT
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
The first line antituberculosis drugs, isoniazid, rifampicin and pyrazinamide continue to be the effective in the treatment of tuberculosis; however, their use is associated with toxic reactions in tissues, particularly in the liver, leading to hepatitis. Hepatotoxicity has been reported in Indian patients at a high risk (up to 11.5%) than in their western counterpart (up to 4.3%). Since all the drugs used in the treatment of tuberculosis are shown to have hepatotoxic effects, studies have been performed to prevent or reduce the toxicity by the use of natural herbal drugs without interfering with the therapeutic actions of the drugs. Management of liver disease is still a challenge to the modern medicine. In the absence of reliable liver-protective drugs in the allopathic medical practices, herbs play a vital role in the management of liver disorders. In traditional medicine, the plants have been used to cure jaundice. In Indian ayurvedic medicine, the oral administration of extracts of dried rhizomes and roots are claimed as a cure for human viral hepatitis. The present review summarizes the list of plants/herbal formulations studied for their hepatoprotective activity in antitubercular drugs-induced hepatitis. However, despite extensive positive research data from experimental studies for herbal drugs in antitubercular drugs-induced hepatitis, and a clinical study, large scale clinical trials are needed to explore the hepotoprotective potential of herbal medicines in antitubercular drugs-induced hepatotoxicity.
Authors and Affiliations
Vinay Kumar*| Assistant Professor & Head, Department of Pharmacology, KIET School of Pharmacy, Ghaziabad, U.P., India, Ankur Sharma| M. Pharm. Research Scholar, Department of Pharmacology, KIET School of Pharmacy, Ghaziabad, U.P., India, Lalit Machawal| Department of Pharmacology, Panjab University, Chandigarh, Punjab, India, Ahmed Abdullah Khan| M. Pharm. Research Scholar, Department of Pharmacology, KIET School of Pharmacy, Ghaziabad, U.P., India.
Keywords
Related Articles
- EP ID EP1751
- DOI -
- Views 397
- Downloads 22
Immunological exploration of virally infected and non-infected leaves of Tobacco plant on human whole blood and peripheral blood mononuclear cells
Introduction- Virally infected plants are of great concern especially for farmers including researchers because of enormous loss and cause disease in different crops e.g. vegetables, fruits, cereals etc. In this study, o...
FORMULATION DEVELOPMENT AND EVALUATION OF TABLETS CONTAINING ANOECTOCHILUS FORMOSANUS EXTRACT: PROCESS OPTIMISATION BY FULL FACTORIAL DESIGN
AnoectochilusformosanusHayata (Orchidaceae) is an indigenous and valuable Taiwanese medicinal plant and has been used popularly as a nutraceutical herbal tea in Taiwan and other Asian countries.The present research inves...
ISOLATION AND EVALUATION OF DISINTEGRATING PROPERTIES OF BASELLA ALBA Linn. LEAF MUCILAGE IN TABLET FORMULATIONS
There are number of synthetic polymers are available in market for pharmaceutical formulations, but these synthetic polymers have certain disadvantages such as high cost, toxicity, environmental pollution during synthesi...
Effect of Electromagnetic Radiations on Anxiety Related Behavior: A Review
Electromagnetic radiation (EM radiation or EMR) is a form of energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels through space. Anxiety is a normal human emotion that everyon...
Role of Polysaccharides isolated from Nepeata septemcrenata in diabetic albino rats
The present study was designed to investigate the antidiabetic activity of polysaccharide extracted from Nepeta septemcrenata (N. septemcrenata). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ)...