Beta-Catenin Expression in Gallbladder Tissues and Its Role in Carcinogenesis and Tumor Progression in Gallbladder Carcinoma
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 2
Abstract
Background: Gallbladder carcinoma is the most common malignancy in the biliary tract, the fifth commonest cancer of the gastrointestinal tract. Oncogenes (beta-catenin) has been shown to be involved in the development and progression of gallbladder carcinoma. The present study has been conducted with an aim to study the expression patterns of beta-catenin in different gallbladder tissues to elucidate the role of this oncogene in carcinogenesis and to evaluate its relationship with tumor progression. Materials and Methods: The study was conducted on histological sections from surgically resected 112 specimens of gallbladder tissue lesions operated at the Department of Surgery, Nehru Chikitsalaya, Gorakhpur which included 66 cases of chronic cholecystitis, 34 cases of gallbladder carcinoma and 12 specimens of gallbladder controls as part of other surgical procedures with no pathology in the gall bladder. Results: Beta-catenin nuclear expression in gallbladder cancer was significantly higher than in chronic cholecystitis and normal gallbladders (P < 0.0001). With increasing (T) depth of tumor invasion (P = 0.0231) and stage of the lesions (p= 0.0226), there is also an increase in the nuclear expression of betacatenin. The level of beta-catenin expression increased from 44.44% in well differentiated (low grade) to 100% in poorly differentiated (high grade) tumor (P = 0.0463).Thus suggesting a role in tumor progression. Conclusion: In present study, it was observed that expression of beta‑catenin get altered in gallbladder carcinoma and has a significant role in carcinogenesis and progression of gallbladder carcinoma.
Authors and Affiliations
Dr Chandrawati
Keywords
Related Articles
- EP ID EP506025
- DOI -
- Views 57
- Downloads 0
A Study of Acute Kidney Injury in Patients with Snakebite Envenomation
Background and Objectives: Since long Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the...
Limited Wegener’s Granulomatosis Associated with Multiple Pyoderma Gangrenosum Lesions in a 30 Year Old Indian Woman
Pyoderma gangrenosm is a neutrophilic dermatosis characterised by rapidly spreading and painful ulceratve lesions. Wegener’s granulomatosus, a small vessel vasculitis can present with cutaneous features in approximaely 1...
Seroprevalence of Transfusion Transmitted Infection among Blood Donors in Government Blood Banks of Chhattishgarh: Retrospective 5 Years Study
Background: Transfusion transmissible infection (TTI) is defined as any infection that is transmissible from person to- person through parenteral administration of blood or blood products. The occurrence of TTIs varies f...
Arrythmiasin Athletes: What Is New?
Sports seem to as old as mankind. Athletic performances, though are of proven long term benefits, tests the capacity of human mind and body. Arrhythmias that occur during or shortly after exercise are labelled as Exercis...
Seroprevalence of Transfusion Transmitted Infections among Blood Donors in a Tertiary Care Hospital in Madhya Pradesh
Background: Blood transfusion is a life-saving procedure. However, the recipient has the potential risk of acquiring transfusion-transmissible infections (TTI), important infectious agents being Human Immunodeficiency Vi...