An Open Label, Prospective Study to Evaluate the Efficacy of Misoprostol Versus Dinoprostone Gel For Induction of Labour

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An Open Label, Prospective Study to Evaluate the Efficacy of Misoprostol Versus Dinoprostone Gel For Induction of Labour

Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 2

Abstract

Objective: This prospective study was conducted to compare the effect, efficacy & safety of intra-vaginal misoprostol (PGE1) & intra-cervical dinoprostone gel (PGE 2) for induction of labour. Methods: 60 women aged 18-35 years with single live fetus, cephalic presentation & term pregnancy, who were admitted for induction of labour were included in this study.30 women received intrvaginal 25 microgram Misoprostol (study group) & 30 women received 0.5mg of intracervical dinoprostone gel(control group). Comparison was done between the mean time taken for onset of labour, time taken for induction to delivery, mean duration of labour, requirement of Oxytocin augmentation, mode of delivery, side effects & the neonatal outcome in either of the groups. Results: The mean time taken for onset of labour was less in the misoprostol group than in the dinoprostone group (58.22 min and 1 hr 55 min). Similarly duration from induction to active phase (1hr 57 min and 4hrs 25 min) and active phase to delivery ( 3 hrs 21 min and 5 hrs 9min) was less for misoprostol group and thus the induction to delivery interval (5 hrs 18 min and 9 hrs 34 min). Cesarean section rate was less in misoprostol group (10% v/s 24%). Maternal side effects were minimal in either group & the neonatal outcome was good in both the groups. The induction cost was much less in the misoprostol group. Conclusion: Misoprostol is safe, efficacious, cheap and mother and fetus friendly drug for the induction of labour

Authors and Affiliations

Dr Deepanjali Lomte

Keywords

Induction of labour Misoprostol Dinoprostone gel.

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EP ID EP213307
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