BIFENTHRIN INDUCED BIOCHEMICAL AND HISTOPATHOLOGICAL ALTERATIONS IN RATS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 5
Abstract
Bifenthrinis a third-generation synthetic pyrethroid with a broad spectrum insecticidal and acaricidal activity used to control a wide range of insect pests in many applications. The current study was designed to investigate the toxic effects of bifenthrin in male rats exposed orally by stomach intubation at 7 mg/kg for 28 days. Liver and kidney functions were monitored in addition to oxidant/antioxidant parameters inserum, liver, kidney and brain. The immunohistochemical reactivity to iNOS, COX-2 and caspase-3 were studied and the histopathological findings were recorded. Our results revealed significant elevations in serum ALT, AST, LDH and ALP activities and blood BUN and creatinine levels while serum total protein was reduced. The level of MDA increased in liver, kidney and brain with reduction in GSH level and SOD, CAT and GPx activities. The activity of iNOS increased in hepatocytes, glomeruli and renal tubular cells. Strong immunoreactivity to COX-2 was observed in the brain. The expression of caspase-3 increased in both liver and brain. The liver revealed degeneration with loss of cellular outlines and areas of coagulative necrosis infiltrated with inflammatory cells. The kidney showed congestion of blood vessels and glomeruli, necrotic renal tubules and hyperplasia of fibrocytes with leucocyte infiltration in-between renal tubules. The brain revealed loss of some Purkinje cells, demyelination, neuronophagia, widespread neuronal necrosis with marked edema and proliferation of perineural satellite oligodendroglia cells around the cell body of motor neurons ?satellitosis?. In conlusion, bifenthrin produced toxic effects in rats which seem to be mediated by oxidative stress and release of inflammatory mediators.
Authors and Affiliations
Enas A. Tahoun, Shimaa M. Abou-Zeid and Huda O. AbuBakr.
Keywords
Related Articles
- EP ID EP598768
- DOI 10.21474/IJAR01/9006
- Views 48
- Downloads 0
OUR EXPERIENCE OF RHOMBOID EXCISION WITH LIMBERG FLAP RECONSTRUCTION IN PILONIDAL SINUS DISEASE.
Background: Pilonidal sinus is a hair containing sinus at the cleft of buttocks. The treatment should have rapid cure that allows patients to return quickly to their normal activities, with minimum morbidity. Limberg fla...
LEAD POISONING IN CHILDREN: A DESCRIPTIVE STUDY OF HOSPITALIZED IRAQI CHILDREN WITH LEAD POISONING.
Background: Lead is one of the oldest perhaps most ubiquitous of neurotoxic substances although some of toxic effects of lead were known in earlier times. Aim of study: To evaluate the extent of lead poisoning as a publi...
STUDY THE EFFECT OF SILIBININ ON EXPERIMENTALLY INDUCED MEMORY IMPAIRMENT IN MALE RATS.
Aim of the work: is to study the effect of different doses of silibinin on D-galactoseinduced memory impairment in male rats. Methods:60 male rats were divided into four groups, the first three groups were (10 rats each)...
BENIGN METASTASIZING LEIOMYOMA IN AN ELDERLY FEMALE, A CASE REPORT, AND REVIEW OF THE LITERATURE.
Benign Metastasizing Leiomyoma (BML) is a rare disease mostly seen among women in the fertile period with a previous history or coincidental finding of uterine leiomyoma. We report a case of pulmonary BML from the uterus...
A STUDY TO ASSESS THE PREVALENCE OF WHATSAPP ADDICTION AMONG NURSING STUDENTS OF HIMALAYAN SCHOOL OF NURSING KALA-AMB DISTRICT SIRMAUR, HIMACHAL PRADESH.
Objective:To assess the prevalence of whatsapp addiction among nursing students of Himalayan school of nursing Kala-Amb Himachal Pradesh. Methodology:A cross sectional descriptive study was used, a sample size of 60 nurs...