STUDY THE EFFECT OF SILIBININ ON EXPERIMENTALLY INDUCED MEMORY IMPAIRMENT IN MALE RATS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 12
Abstract
Aim of the work: is to study the effect of different doses of silibinin on D-galactoseinduced memory impairment in male rats. Methods:60 male rats were divided into four groups, the first three groups were (10 rats each) and the fourth group (30 rats) was subdivided in to three subgroups (10 rats each)I-Control group was injected subcutaneously by physiological saline once daily for six weeks II- D-galactose group was injected subcutaneously by 150 mg/kg of D-galactose once daily for six weeks III-Placebo group 10 ml/kg of 0.5 % carboxymethylcellulose solution was injected intraperitonealy once daily for six weeks IV-Silibinin group include IVa(2 mg/kg),IVb(20mg/kg),IVc(200 mg/kg), silibinin was suspended in 10ml/kg of 0.5 % carboxymethylcellulose solution and injectedintraperitonealy once daily for six weeks. Results: D-galactose group produced significant decrease step-through latency, increase time in the dark and increase in tissue malondialdehyde, nitrite, acetylcholine esterase, tumor necrosis factor-alpha level and caspase activity, it produced significant decrease in tissue catalase activity and brain-derived neurotrophic factor level when compared to control group.There was insignificant change in placebo group and silibinin (2 mg/kg) when compared to D-galactosegroup.While, it produced significant change in silibinin(20 mg/kg) and (200 mg/kg) when compared to placebo group, but it still produced significant change in silibinin (20 mg/kg) and silibinin (2 mg/kg) when compared to control group,it produced insignificant change in silibinin (200 mg/kg) when compared to control group. Conclusion: Silibinin has role in memory disorders which develops efficient therapeutic approaches.
Authors and Affiliations
Eman Hamdy Basha, Sahar Ahmed Elsawy, Nermin Mohamed Mady, Salma Elwy Nassar.
Keywords
Related Articles
- EP ID EP436585
- DOI 10.21474/IJAR01/8190
- Views 57
- Downloads 0
EFFECT OF FINISHING AND POLISHING ON MECHANICAL PROPERTIES OF COMPOSITE.
Objective: To evaluate the effect of finishing/polishing systems on the surface roughness, micro-hardness, and modulus of elasticity of different types of composite-resins. Materials and Methods:Specimens were made of fo...
VALVULOPATHIE CARDIAQUE SEVERE SECONDAIRE A LA CABERGOLINE REVERSIBLE APRES L\'ARRET DU MEDICAMENT :A PROPOS D?UN CAS.
Nous rapportons lecasd\'unepatiente de 34 ans consultant pour un ad?nomehypophysaire de 2,2 cm en contact avec le chiasmaoptique. La patiente a ?t?trait?avec 1 mg / semaine de Cabergoline (agonistedopaminergique DA) et a...
ROLE OF LIP PRINTS IN PERSONAL IDENTIFICATION AND CRIMINALIZATION.
Establishing a person\\\'s identity is a very important process in civil and criminal cases. In the field of forensic sciences, the lip prints have been proven to be an imperative tool in identifying a person positively....
COMPARATIVE EVALUATION OF MICROLEAKAGE AND COMPRESSIVE STRENGTH OF GLASS IONOMER CEMENT TYPE IX, ZIRCONOMER IMPROVED AND CENTION N - AN IN VITRO STUDY.
Context:Restorative dentistry is a blend of art and science. Newer restorative materials like Cention N and Zirconomer Improved are giving a challenge to conventional restorative materials. Aims: To evaluate and compare...
DIAGNOSIS OF FIBROCYSTIC DISEASE OF BREAST ON ULTRASOUND.
Clinical examination prior to breast ultrasound include palpation of the breasts, axillae, and supra andinfraclavicular lymph nodes. This part of the examination may revealed isolated nodules in either of four quadrant o...