Bilateral Symmetric Thalamic Metastasis in a Patient with Small Cell Lung Cancer
Journal Title: Cancer Studies & Molecular Medicine – Open Journal - Year 2018, Vol 4, Issue 1
Abstract
A 68-year old woman was referred to our hospital because of dry cough with persistent numbness in the extremities. Chest roentgenogram showed right hilar tumor with mediastinal lymphnode and brain magnetic resonance imaging (MRI) revealed multiple tiny nodules. After performing the transbronchial needle aspiration obtained from subcarinal lymphnode, she was diagnosed with small cell lung cancer (SCLC) accompanied by multiple brain metastasis (clinical stage IV: T4N3M1). After completion of four cycles of chemotherapy, the size of lung lesion was regressed together with complete resolution of brain lesions, and she discharged uneventfully. However, her numbness was remained. Four months later, she was hospitalized again for severe numbness in her trunk and extremities. Brain MRI (contrast-enhanced T1-weighted image) demonstrated new symmetric metastatic lesions in bilateral thalamus (Figure A and B) as well as left putamen. Another two months later, numbness exacerbated and spread from the top to toe with the growing of primary and bilateral thalamic metastatic lesions on computed tomography (CT) (Figure C and D). In spite of whole-brain irradiation, she had suffered from severe numbness, and died of obstructive pneumonia. To our knowledge, this is the first case of bilateral symmetric thalamic metastasis in SCLC with refractory numbness over the whole body.
Authors and Affiliations
Takeshi Saraya
Keywords
Related Articles
- EP ID EP559118
- DOI 10.17140/CSMMOJ-4-123
- Views 98
- Downloads 0
Boosting Response: The Impact of Immune Checkpoint Inhibitors on Radiation Treatment Schedules
The recent FDA approvals of immunomodulatory drugs such as Nivoluvamab (Opdivo), Pembrolizumab (Keytruda) and Ipilimumab (Yervoy) for treatment of Non-small cell lung cancer (NSCLC) and melanoma have renewed interest in...
Current Status of Anti Epidermal Growth Factor Receptor Therapy in the Curative Treatment of Head and Neck Squamous Cell Carcinoma
Squamous cell carcinoma of head and neck is the most common malignancy of the upper aero digestive tract in the world. In this article, we attempt to summarize the role of antiepidermal growth factor therapy (EGFR) in th...
Regulation in Cell Cycle via p53 and PTEN Tumor Suppressors
One of the target effectors of p53 transcription factor is the Phosphatase and Tensin homologue deleted on chromosome 10 (PTEN) which has protein phosphatase activity and lipid phosphatase activity that antagonizes PI3K...
The Emerging Role of p27 in Development of Diseases
The cell cycle regulation and tumor suppressor p27 encoded by CDKN1B plays a key role in many cellular events.1-3 p27 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors, which functions to nega...
Role of Molecular Imaging in Oncology
Molecular Imaging (MI) is an emerging technology for the early detection of disease, staging of the disease, and for monitoring response to therapy. It also offers a non-invasive method to detect in vivo biological funct...