Dosimetric Characterization of an Abscopal Response in a Patient With Oligometastatic Melanoma Undergoing Concurrent Treatment With Pembrolizumab and Stereotactic Body Radiotherapy (SBRT)
Journal Title: Cancer Studies & Molecular Medicine – Open Journal - Year 2018, Vol 4, Issue 1
Abstract
Recently, preclinical and clinical evidence has shown that a synergy may exist between radiation and immune check-point therapies such as pembrolizumab. Radiation has been shown to activate the immune system, and in combination with immunotherapy may lead to systemic anti-tumor responses. However, the exact dose regimens needed to induce synergistic responses are unclear. Here, we report a dosimetric characterization of a patient treated with stereotactic radiation in combination with immune check-point therapy
Authors and Affiliations
Jennifer Sims-Mourtada
Keywords
Related Articles
- EP ID EP559107
- DOI 10.17140/CSMMOJ-4-121
- Views 102
- Downloads 0
Skin Hypopigmentation in a Patient with Papillary Carcinoma Thyroid Treated with Sorafenib
Sorafenib is an oral multikinase inhibitor approved for the treatment of advanced renal cell carcinoma, hepatocellular carcinoma and thyroid cancer. The dermatological side effects of sorafenib include palmar-plantar ery...
Bilateral Symmetric Thalamic Metastasis in a Patient with Small Cell Lung Cancer
A 68-year old woman was referred to our hospital because of dry cough with persistent numbness in the extremities. Chest roentgenogram showed right hilar tumor with mediastinal lymphnode and brain magnetic resonance imag...
How Target Therapy can Induce Cardiotoxicity: The Onco-Cardiologist Point of View
The life expectancy of an oncological patient has been increased significantly decades due to the evolution of cancer therapies. The aim of this paper is to review how these new target molecules, which have a direct impa...
Role of Molecular Imaging in Oncology
Molecular Imaging (MI) is an emerging technology for the early detection of disease, staging of the disease, and for monitoring response to therapy. It also offers a non-invasive method to detect in vivo biological funct...
Elimination of Tumor Suppressor Proteins during Liver Carcinogenesis
Liver cancer is one of the most lethal cancers. Quiescent liver expresses up to 20 tumor suppressor proteins including Rb, p53, CCAAT-Enhancer-Binding Protein (C/EBP)α, Hepatocyte Nuclear Factor (HNF4)α and p16 and it is...