Bile acids in organisms of healthy and sick newborn calves and after applying enterosorbents
Journal Title: Біологія тварин - Year 2014, Vol 16, Issue 2
Abstract
Taking into consideration the crucial role of bile acids in the processes of digestion and assimilation of feed components of lipid nature, intermediate metabolism of bile acids in the body of newborn calves suffering from dyspepsia was investigated. Analysis of the data shows that in calf's bile appear differences of the ratio of individual bile acids and a significant decrease in their total content. Seven fractions of conjugated and free bile acids, including the dominated taurocholic, taurohenodesoksicholic, taurodezoksichoic, hlikocholic acid are identified. It was found that on the background of reduction of bile acids conjugated with taurine and glycine in gallbladder bile and liver of newborn calves suffering from acute indigestion, the level of free bile acids increases significantly. This indicates a decrease in biosynthetic and conjugating liver function of patients with dyspepsia in calves. In addition, the increasing toxic litocholic acid. Analysis of extracts from the colon diseased calves showed that the total content of bile acids significantly increased. This indicates that the body of sick animals lose large amounts of the compounds and the significant variations in entnrohepatycal cycle of the gastrointestinal tract. In the bile and the contents of the colon in patients calves serum total bilirubin significantly increased. Thus, its content in bile of patients calves 1.2 times greater than in the control, and the contents of the colon is almost twice the control value. These data indicate that the body of sick calves under the influence of certain factors, including elevated levels of LHA, intensified hemoglobin break down simultaneously with the reduction of the term of erythrocytes half-life. Apply for therapeutic purposes enterosorbents partially or fully stabilize certain level of bile-acid metabolism in the body of experimental animals and most of their recovery.
Authors and Affiliations
V. A. Tomchuk
Keywords
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