Bio-Modulation of Platelet Count Following the Administration of Tender Coconut Water in New Zealand Male Rabbits
Journal Title: Tropical Journal of Natural Product Research - Year 2019, Vol 2, Issue 8
Abstract
Received 28 June 2017 Revised 25 June 2018 Accepted 22 July 2018 Published online 10 August 2018 Coconut is a fruit of great health benefits. This study was aimed at investigating the biomodulatory effect that oral ingestion of tender coconut water (TCW) exerts on the body during acute inflammatory processes in New Zealand male rabbits. A longitudinal study was adopted in this study using fifteen rabbits (n = 15) and having 4 treatments comprising them. Treatment 1 served as the basal stage without TCW administration. Treatment 2 includes 2 weeks post coconut water administration. Treatment 3 includes 4 weeks post TCW administration. Treatment 4 includes withdrawal of TCW administration. Oral doses of TCW, 5 mL/kg body weight were administered daily and maintained for six weeks. Blood samples were collected at weeks 2, 4 and 6 for the estimation of haematological parameters including white blood cell counts (WBC) and differentials, erythrocyte sedimentation rate (ESR), platelet counts and C-reactive protein concentration. Monocyte concentration (11.07 ±1.19%) in treatment 2 was significantly (p < 0.05) higher than those of treatment 1, 3 and 4%. Platelet concentration in group 1 was increased significantly (p < 0.05) compared to treatments 2 and 3 following the administration of TCW and increased again upon withdrawal of TCW [treatment 4 (280.27 ± 25.30 x 109/L)]. C-reactive protein was increased significantly in treatment 1 (2.93 ± 0.42) compared to treatments 2, 3 and 4. The data obtained from this study showed that the physiology of platelet during acute inflammatory conditions may be modulated by the administration of TCW.
Authors and Affiliations
Ese Onuyoh-Adaitire
Keywords
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- EP ID EP495933
- DOI 10.26538/tjnpr/v2i8.7
- Views 99
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