Bioanalytical method development and validation of bleomycin sulphate
Journal Title: Journal of Applied Pharmaceutical Research - Year 2017, Vol 5, Issue 2
Abstract
Bleomycin is an anti-neoplastic drug that has recently been used for the treatment of vascular anomalies. An expedient method was developed for the determination of plasma bleomycin levels using ion-paired reversed phase high performance liquid chromatography (HPLC). The concentration was found to be proportional to the area and the response of the detector was determined to be linear over the range of 1-6 µg/ml for both Bleomycin A1 and Bleomycin B2. Recovery was approximately 100%. This method provides a simple and rapid way of determining the levels of bleomycin A2 and B2 in human and rat plasma
Authors and Affiliations
Yash Prashar, Harkaran Rana, Souravh Bais
Pharmacognostic Evaluation and Physico-chemical Analysis of Ulmus wallichiana Planch.
The plant Ulmus wallichiana Planch. (Family: Ulmaceae) is found in Himalayan regions from Afghanistan to West Nepal. In India, it is found in Kumaun and Garhwal hills of Uttarakhand (India), locally known as Chamarmou. B...
A review on the pros and cons of online pharmacies
Buying medicines online is common practice across the globe these days. This is because buyers are preferring to order for medicines through a click of a button rather than taking a trip to a drug store. Such online webs...
Liposome: method of preparation, advantages, evaluation and its application
Notable research in drug delivery started in 1950’s with the advent of polyclonal antitumor antibodies developed for targeting. Bangham et. Al. discovered liposomes in early 1960’s. In this review article we are discussi...
Chemometric – assisted UV spectrophotometric method for determination of antihyperlipidemic agents in pharmaceutical formulation
This presented work is based on application of two multivariate calibration methods for simultaneous UV-VIS spectrophotometric determination of active substances in combined pharmaceutical formulation composed of Atorvas...
A nanocrystal technology: to enhance solubility of poorly water soluble drugs
Most of the recently developed new chemical entities are poorly water soluble and they create major problems during formulation and development of new dosage form and due to poor solubility and poor bioavailability. The...