Biochemical Assessment of Parkia biglobosa Ethanolic Root Extract in Streptozotocin Induced Diabetic Rats
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2017, Vol 13, Issue 1
Abstract
Aim: To investigate the antidiabetic effect of Parkia biglobosa ethanolic root extract in streptozotocin induced diabetic rats. Place and Duration of Study: Department of Biochemistry, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji Arakeji Osun State, Nigeria, between October 2014 and August, 2015. Methodology: Sixty adult female Wistar rats weighing between 120-190 g were divided into six study groups I, II, III, IV, V, VI, (n=8) weighing between 120-190 g. Group 1 was designated as positive control and received distilled water, group II was designated as negative control and received (1 ml) of streptozotocin, group III was designated as diabetes induced and orthodox and received (1 ml) of Insulin, groups IV, V and VI were designated as diabetes induced and extract treated groups and received (250 mg/dl, 500 mg/dl and 1000 mg/dl) respectively. Results: The phytochemical screening of the ethanolic root extract showed the presence of flavonoids, tannin, saponins, cardiac glycosides, phenolics, terpenoid and oxalate. There was a significant decrease in blood glucose levels of diabetes treated groups VI, V and VI at the end of the experiment which portrays the therapeutic efficacy of Parkia biglobosa ethanolic root extract in ameliorating diabetic condition. There was a significant decrease in Alanine transaminases (ALT), Aspartate transaminase (AST) and Alkaline phosphotase in extract treated groups compared with negative control. However, Total cholesterol, High density lipoprotein (HDL), and Triglycerides (TG) shown increase which was not significant compared to the negative control but Low density lipoprotein (LDL) depicted decrease which was significant compared with the negative control. Conclusion: The results obtained from all these assays justify the therapeutic efficacy of Parkia biglobosa root extract to ameliorate diabetic condition.
Authors and Affiliations
R. U. Ukpanukpong, I. A. Adekunle, C. O. Adeleke
Keywords
Related Articles
- EP ID EP311619
- DOI 10.9734/JAMPS/2017/24877
- Views 72
- Downloads 0
Zidovudine-Induced Anaemia in Human Immunodeficiency Virus Infected Children on Highly Active Anti-Retroviral Therapy in Jos, Nigeria
Aims: To determine the incidence and severity of zidovudine-induced anaemia in HIV-infected children initiated on anti-retroviral therapy in Jos, Nigeria. Study Design: This was an observational cohort study. Place and D...
Evaluation of Right Ventricular Diastolic Function in Patients with Chronic Obstructive Pulmonary Disease Using Pulsed Doppler Tissue Imaging
Objective: To evaluate the global and segmental diastolic function of the right ventricle using pulsed tissue Doppler imaging (TDI) in patients with clinically stable chronic obstructive pulmonary disease (COPD) without...
Comprehensive Patients’ Self-reported Causes of Non-compliance to Antihypertensive Medications in Maiduguri, Nigeria
Background: Many strategies have been employed to improve compliances to antihypertensive medications but these efforts are not translated into good compliances with several patients leading to high cases of morbidity an...
A Review: Ethnomedicinal, Phytochemical and Pharmacological Investigations of Lannea welwitschii (Hiern) Engl.
Ethnopharmacological Relevance: Lannea welwitschii (Hiern) Engl. (Synonyms: Calesiam welwitschii, Lannea acidissima, Lannea amaniensis), of the family Anacardiaceae is a woody plant that is employed in African traditiona...
Detection of Extended Spectrum β-Lactamase Producing Escherichia coli in Neonatal Unit of a Tertiary Health Institution, South-South Nigeria
Aims: To determine the prevalence of multidrug resistant (MDR) and Extended Spectrum β-lactamase producing (ESBL) E. coli in neonates, their mothers and healthcare workers (HCWs) in the neonatal wards of the University o...