Biochemical effect of curcumin on hyperlipidemia induced in rats
Journal Title: Medicamentul Veterinar / Veterinary Drug - Year 2016, Vol 10, Issue 1
Abstract
This study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholesterol-enriched diet. Forty female adult albino rats were divided into four equal groups of 10 rats each. Group (1): negative control received normal diet only, group (2): rats fed on normal diet and received curcumin orally, group (3): positive control received hyperlipidemic diet, group (4): rats fed on hyperlipidemic diet and received curcumin (350 mg/ 1 kg b.w.) orally. The obtained results revealed that, curcumin supplementations to hyperlipidemic rats showed a significant increase in serum HDL-cholesterol, nitric oxide, adiponectin and Endothelin-1 concentrations and significantly decrease in serum total cholesterol, triacylglycerols, LDL cholesterol, Fasting blood glucose, Glycated Hemoglobin (HbA1C), high sensitive C-reactive protein and Interleukin-6 levels. These results suggest that, curcumin supplementations may have some benefits in patients suffering from dyslipidemia and diabetes.
Authors and Affiliations
A. Omayma , K. Hassanin , M. Abdelghaffar
Keywords
Related Articles
- EP ID EP96143
- DOI -
- Views 148
- Downloads 0
Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography
The study describes the development of a HPLC -DAD method for the estimation of oxytetracycline and furazolidone in Enteroguard M - powder. The proposed method utilizes a Betasil C 18 column, (4.6 x 250 mm, 5 µm), at 300...
Elemente de terapie alternativă și complementară în medicina veterinară
No abstract
Dezvoltarea şi validarea metodei RP–HPLC de determinare cantitativă a albendazol din suspensii de Rombendazol
A fost dezvoltată şi validată o metodă isocratică de lichid cromatografie de performanţă înaltă pentru determinarea cantitativă a albendazol din suspensii ROMBENDAZOL. Separarea HPLC a fost realizată prin cromatografie î...
Instructions for Authors
Raport asupra studiului colaborativ pentru stabilirea potenței standardului de referință: Rifamicină
Laboratorul Control Microbiologic din cadrul Institutului pentru Controlul Produselor Biologice și Medicamentelor de uz Veterinar a participat la studiul colaborativ pentru determinarea potenței lotului 4 de rifamicină,...