Biochemical effects in patients of pediatric nephrotic syndrome related Vitamin D and Calcium metabolism
Journal Title: International Journal of Medical and Health Research - Year 2017, Vol 3, Issue 7
Abstract
Minimal Change Disease (MCD) is the leading cause of childhood Nephrotic Syndrome (NS). Therefore in pediatrics nephrotic syndrome, most children beyond the first year of life will be treated with corticosteroids without an initial biopsy. Children with NS often display a number of calcium homeostasis disturbances causing abnormal bone histology, including hypocalcemia, reduced serum vitamin D metabolites, impaired intestinal absorption of calcium, and elevated levels of immunoreactive parathyroid hormone (iPTH). These are mainly attributed to the loss of a variety of plasma proteins and minerals in the urine as well as steroid therapy. Early diagnosis and management of these abnormalities, could prevent the growth retardation and renal osteodystrophy that affects children with nephrotic syndrome. Here we reviewed the literature for changes of calcium and vitamin D metabolism in nephrotic syndrome and its consequences on bones, also the effect of corticosteroid and possible preventive strategies that could be done to avoid long term outcomes in children. Although the exact biochemical basis for Changes in levels of calcium and vitamin D metabolites in patients with NS remains speculative; Because of the potential adverse effects of these changes among growing children, widespread screening for vitamin D deficiency or routine vitamin D supplementation should be considered.
Authors and Affiliations
Naresh Manne, Krishna Chaitanya Paleti
Keywords
Related Articles
- EP ID EP586044
- DOI -
- Views 125
- Downloads 0
Effectiveness of low impact versus high impact exercises to improving the functional ability in osteoporotic females
Background: Osteoporosis is a condition characterized by a decrease in the density of bone, decreasing its strength and resulting in fragile bones. Physical activity helps reduce the rate of bone mineral loss that occurs...
Fungal infections in chronic stable bronchiectasis patients
Bronchiectasis is a chronic and etiologically heterogeneous disease, which is commonly characterized by a vicious circle of impaired mucociliary clearance, bronchial infection and inflammation, resulting in structural ai...
Ayurvedic protocol for prevention and management of chronic toxicity of chemotherapy
Chemotherapy is a common treatment used for patients of cancer. Chemotherapy and its chronic toxicity have been mentioned in Ayurveda under the heading of kshara-karma and kshara-vyapada respectively. Even the properties...
Efficacy of Veratrum album in treatment of primary dysmenorrhoea
Introduction: Present scenario dysmenorrhoea decreases women quality of life, work productivity and health. Commonly school girls, college students, etc. are affected by primary dysmenorrhoea. It is reported that 93% of...
Effect of application site of definitive cement on marginal adaptation and retention of full metal crowns: An in vitro study
Background: Hydrodynamic pressure due to excess luting agent and insufficient seating pressure prevents complete seating of restorations. Incompletely seating may lead to disturbances in occlusion and interproximal conta...