Biochemical evaluation of vitamin D levels in pre diabetes, type 2 diabetes mellitus and its correlation with glycated hemoglobin
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2018, Vol 5, Issue 4
Abstract
Introduction Globally 1 billion people are suffering with deficiency or insufficiency of vitamin D Vitamin D deficiency is also associated with metabolic disorders This study evaluates Vitamin D levels in prediabetes T2DM patients and its correlation with HbA1cMaterials and Methods This study was done in Department of Physiology in association with Department of Endocrinology JNU Institute of Medical Sciences Research Center Jaipur A total of 155 subjected were enrolled into the study They were divided into three groups 65 age and gender matched healthy subjects were taken as group I controls HbA1c 55 to 65 45 prediabetic subjects were taken as group II HbA1c 65 to 75 and 45 T2DM subjects were taken as group III HbA1c 75 Age of the study subjects was 45 to 65 years Serum sample was used for the estimation of random sugar GODPOD method by using ERBA chemistry analyzer vitamin D by ELISA method using mini VIDAS and EDTA sample for HbA1c by using BIORAD D10Results In this study random blood sugar and HbA1c levels were significantly elevated in pre diabetic group II T2DM group III subjects compared with controls group I Significant reduction was observed in prediabetic T2DM subjects compared to controls in respect to vitamin D levels Negative correlation was observed between HbA1c and vitamin DConclusion In conclusion the results of this study showed significant reduction and negative correlation between serum vitamin D levels and HbA1c in prediabetic and T2DM patients This study results indicates that there may be need to screen pre diabetic and T2DM patients with poor glycemic control for Vitamin D status Keywords Glycated hemoglobin Glycemic control T2DM Vitamin D deficiency
Authors and Affiliations
Ajit Thakur, Suresh Nayak B, Gayathri L, Prithvi Nayak
Keywords
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- EP ID EP476110
- DOI 10.18231/2394-2126.2018.0110
- Views 61
- Downloads 0
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