Biochemical Hyperthyroidism of Hydatidiform Mole: “Hooked” with a Grapy Case
Journal Title: The Indian Practitioner - Year 2016, Vol 69, Issue 5
Abstract
Molar pregnancy is an abnormal form of pregnancy in which a non-viable fertilised egg implants in the uterus and would fail to come to term. A molar pregnancy is a gestational trophoblastic disease which grows into a mass in the uterus that has swollen chorionic villi. These villi grow in clusters that resemble grapes.1 Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, ranging from molar pregnancy to choriocarcinoma.2 Hydatidiform pregnancy occurs in 1:1000 pregnancies worldwide3 while incidence in India is 1:400 of pregnancies. Prevalence of hyperthyroidism in molar pregnancy is as high as 7%.3 Hyperthyroidism occurs due to molecular mimicry between (hCG) and (TSH) receptors resulting in cross-reactivity.5 Clinical hyperthyroidism due to trophoblastic disease is cured by evacuation of molar tissue.3,6 It may require treatment with anti-thyroid drugs.4 Excess quantity of β-hCG leads to interference in immunoassay giving false negative or low results due to high dose hook effect.
Authors and Affiliations
M K, Padwal, G C Gawade, R R Melinkeri
Keywords
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