Biochemical investigation - diagnostic tools of multiple myeloma
Journal Title: Journal of Research in Biology - Year 2014, Vol 4, Issue 5
Abstract
In this study biochemical technique was used as supportive tool for early diagnosis of multiple myeloma suspected cases. Samples of suspected cases were collected from histopathological diagnostic center. Serum calcium, serum albumin and Total protein were estimated. Bence jones protein was estimated in urine sample. Gel Electrophoresis was employed to resolve serum protein according to their molecular weight. The serum calcium level was very high (14.9 – 18mg/dl) than normal (9 -11mg/dl). When compared to normal serum albumin value, the test serum albumin level was decreased (2.7 – 3.2mg/dl). The total protein was increased because of the accumulation of para protein in blood stream. Light chain of immunoglobulins found as bence jones protein in the urine sample. The gel electrophoresis image revealed that the intensity of monoclonal protein (‘M’ Protein) was higher than other separated bands. The results suggested that this low cost biochemical technique may be used for the diagnostic purpose of Multiple myeloma at the earlier stage
Authors and Affiliations
Muthukumar N, John De Britto A, Harry Thomas Rodriquez A, Rekha Sunder
Keywords
Related Articles
- EP ID EP567141
- DOI -
- Views 94
- Downloads 0
Diversity and conservation status of water birds at Upper lake, Bhopal – A Ramsar site in central India
Wetlands support considerable biodiversity including water birds. In central India, the Upper lake of Bhopal is designated as a Ramsar site and IBA status concerning to its diverse avifauna. At present, a detailed study...
Laboratory toxicity evaluation of Diflubenzuron, a chitin-synthesis inhibitor, against Anopheles darlingi (Diptera, Culicidae)
We evaluated Diflubenzuron toxicity against larvae and pupae of Anopheles darlingi. A series of bioassays were developed to assess the lethal concentrations LC50 and LC90 to larvae after two exposure periods (24 and 48 h...
Foliar spray of Earthworm urine to improve Amaranthus growth performance and yield
The effects of foliar spray of earthworm urine on plant growth parameters and greengrocery values were studied on the leaf vegetable Amaranthus. The application caused 28% increase in plant height, 166% increase in plant...
Effect of plant growth regulators on in vitro organogenesis in cultivated tomato (Solanum lycopersicum L.)
An efficient and reproducible protocol for organogenesis from cotyledon explants in cultivated tomato (Solanum lycopersicum L.) cv S-22 is reported. The cotyledon explants of 10-12 days old excised from in vitro grown se...
Identification of dust storm sources area using Ackerman index in Kermanshah province, Iran
Dust storms are one of the most important environmental challenges in the last decade at Kermanshah province, which greatly endangers the health of all living things, especially humans. The first step in controlling this...