Bioenhancers from Mother Nature: A Paradigm for Modern Medicines
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 10
Abstract
Pharmaceutical corporations round the globe have continually been within the urge of discovering innovative blockbuster medicine for numerous ailments by outlay billions of bucks for the drug discovery programmes. With the development of various molecules pharmaceutical science has gained a lot of success. However, the newly discovered molecules suffer various drawbacks such as poor aqueous solubility, lack of suitable bioavailability etc. The metabolism of API by cytochrome P450 (CYP) DMEs within the gut wall and within the liver is the major process which is responsible for reduced bioavailability of drug. Additionally to the present, EDTs like P glycoprotein (P gp), multidrug resistant associated protein (MRP) are also liable for reduced bioavailability of the therapeutically active medication, particularly metastatic tumor medication. Therefore, a certain alternative is needed which can enhance the bioavailability of these drug molecules. Bioenhancers plays a vital role in modifying the pharmacokinetic and pharmacodynamic profile of these drugs. A bioenhancer is an agent which when co-administered with the drug, enhances its bioavailability. Herbal bioenhancers play an important role in enhancing the bioavailability and efficacy of various categories of medicine, like antihypertensives, anticancer, antiviral, antitubercular and antifungal medication at low doses. This paper demonstrates numerous natural agents including quercetin, genistein, naringin, sinomenine, curcumin, and glycyrrhizin as potent bio enhancer’s drugs and additionally describes planned mechanism of action that in the main includes absorption method, drug metabolism, and action on drug target. The bioenhancers are simply accessible, safe, and free from side effects, minimizes drug toxicity, shortens the period of treatment, lowers the drug resistance issues and minimizes the value of treatment. This review also presents a detail study about various aspects of bio enhancer and a short account of the various natural products showing enhancing effect.
Authors and Affiliations
Dr. Surender Verma, Suchita Rai
Keywords
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