Mathematical Models of Drug Dissolution: A Review
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 5
Abstract
When a new solid dosage form is developed, it is very important to study drug release or dissolution. The quantitative analysis of values obtained in dissolution or release rates is easier when mathematical formulae are used to describe the process. The mathematical modeling helps to optimize the design of a therapeutic device to yield information on the efficacy of various release models. In this paper we review the different mathematical models used to determine the kinetics of drug release from drug delivery systems such as, zero order, first order, Hixson-Crowell, Higuchi, Weibull, Korsemeyer-Peppas, Hopfenberg, Baker-Lonsdale and Gompertz model. Keywords: Dissolution, Dissolution models, Drug release kinetics.
Authors and Affiliations
Ramteke K. H, Dighe P. A, Kharat A. R, Patil S. V
Keywords
Related Articles
- EP ID EP377960
- DOI -
- Views 133
- Downloads 0
Phyto Pharmacology and Ethnomedical Approach of Terminaliachebula (Kadukkaai): A Review
Traditional medicine can take part a significant task in achieving the goal of ‘Health for All’ and is offered to assisting the integration of traditional medicine with Western medicine all over the world (WHO). As a par...
Synthesis, Characterization and Pharmacological Evaluation of Novel Mannich bases of Thienopyrimidine Derivatives
Thienopyrimidines has received considerable attention as they are endowed with variety of biological activities and have wide range of therapeutic properties. Thienopyrimidines, the structural analogues of biogenic purin...
A Valuable Insight Impact of Pharmacist in Pharmacogenomics
Pharmacogenomics is the study of genetic variations that influence individual response to drugs. Knowing whether a patient carries any of these genetic variations can help prescribers individualize drug therapy, decreas...
Medicinal plants affected reproductive systems (part 2) - plant based review
In our previous paper, we reviewed the reproductive effects of many medicinal plants included Achillea santolina, Ailanthus altissima, Alhagi maurorum, Allium cepa, Althaea rosea, Ammannia baccifera, Anthemis nobelis,...
Evaluation of Toxicity Profiles of Siddha Metallic Preparation of ‘AyaChendooram’ In Laboratory Animals
Ayachendooram (AC), a widely used Siddha metallic preparation consist of purified iron fillings, vinegar and odina bark juice. The formulation was evaluated for acute and chronic toxicity in rats with reference to histop...