Biogenesis of microRNAs and their role in the development and course of selected hematologic disorders
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
MicroRNAs (miRNAs) are a group of small molecules, about twenty nucleotides in length.They are involved in the regulation of gene expression mainly at a posttranscriptional level. Thisfunction depends on their complementarity to the 3’UTR regions of mRNAs. MicroRNAsare essential for proper development and functioning of the organism. They are so importantbecause of their participation in such processes as angiogenesis, apoptosis, cell cycle control andoncogenesis. Over thirty percent of human genes are controlled by miRNAs. This indicates thegreat importance of these molecules. Alterations of numerous cellular processes can be causedby the dysregulation of miRNA expression. Such disturbances are observed in cancer cells, andsignatures of microRNA expression are specific to particular types of cancer. It is suggested thatmiRNAs may serve as diagnostic and prognostic factors in oncologic and hematooncologic disorders. The expression of specific miRNAs can indicate benign or aggressive course of disease.The overall survival or time to treatment are also possible to estimate based on the microRNAexpression profile. Knowledge about changes in miRNA expression observed in leukemia patientsmay enable the selection of appropriate individual therapy. Recent reports indicate that varioushematooncologic disorders may be well characterized by microRNAs circulating in plasma orserum. It is of great potential importance, considering the availability of material for analysis,simplicity of diagnostic procedures and shortening of time required to conduct them.
Authors and Affiliations
Anna Grenda, Michał Budzyński, Agata Filip
Keywords
Related Articles
- EP ID EP66879
- DOI -
- Views 163
- Downloads 0
Zastosowanie stężenia wybranych białek neutrofili w osoczu w diagnostyce choroby Leśniowskiego-Crohna i wrzodziejącego zapalenia jelita grubego – doniesienie wstępne
Hemodializa bez heparyny
Hemodialysis is the most widely applied renal replacement therapy. Due to the fact that the hemocyte - dialyzer contact leads to the activation of the coagulation pathway, adequate anticoagulation to provide fluent blood...
SMAD family proteins: the current knowledge on their expression and potential role in neoplastic diseases
Transforming growth factor beta (TGF-β) plays a crucial role and takes part in many processes in the human body both in physiology and pathology. This cytokine is involved in angiogenesis, regulates apoptosis and stimula...
Heterotopia trzustkowa i żołądkowa w przewodzie pokarmowym
Pathogenesis, prophylaxis and treatment of infections in patients with chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) patients are at high risk for infections. The pathogenesis of infection in patients with this leukemia is complex and multifactorial. Patients with CLL have a number of immune system de...