Biological investigations of different leaf extracts of Litsea liyuyingi (Family-Lauraceae)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
In this present study, the leaf extracts of Litsea liyuyingi, were subjected to evaluate the phytochemical screenings, thrombolytic, membrane stabilizing, antioxidant, antimicrobial, cytotoxic, antinociceptive, anti-diarrheal and hypoglycemic activity. In phytochemical screening the presence of flavonoids, saponins, alkaloids, phenols and tannins were detected in the plant leaf extract. Methanol (43.55%) extract and its pet-ether fraction (42.11%) showed good thrombolytic effects and good membrane stabilizing effects were observed by carbon tetrachloride and aqueous soluble fractions respectively. Two different assays were performed to evaluate antioxidant activity. The presence of phenolic contents and free radical scavenging activity was remarkable in the methanol extract and its pet-ether fraction. Crude methanol extract and other fractions showed effects against gram positive and gram negative bacteria as well as demonstrated effects to A. Salina with LC50 values ranging from 1.04 to 9.41 g/ml and LC90 values ranging from 30.20 to 82.14 g/ml as compared to contro. Statistically significant (**p<0.01; ***p<0.001) result was found in case of in vivo antinociceptive activity test for the 400 mg/kg methanol extract when compared to control. The crude methanol extracts of leaves also possessed significant anti-diarrheal (*p<0.05) and hypoglycemic (**p<0.01) activity at 400 mg/kg.
Authors and Affiliations
Farhina Rahman Laboni, Salman Mahmud, Samira Karim, Sajan Das2, Mohammad Shahriar2
Keywords
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- EP ID EP388786
- DOI 10.9790/3008-1202040817
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