The Effect of Berchemia Berchemiifolia to Moderate Gastric Mucosal Bleeding Caused by the Exposure to Acute Intense Stress
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
To evaluate the effect to moderate gastric ulcer caused by acute intense stress, this study used an experimental animal model of gastric ulcer triggered by waterlogging stress. Experimental animal groups are divided into control group; vehicle group; 200 mg/kg rat weight berchemia berchemiifolia extract oral administration group; 50 mg/kg rat weight berchemia berchemiifolia extract oral administration group; and 3 mg/kg rat weight ranitidine oral administration group (positive control). The substances were administered before imposing waterlogging stress. After 6 hours of waterlogging, the animals were sacrificed, and samples were collected. The level of gastric mucosal bleeding, inflammatory gastric cells, and inflammatory protein (iNOS, Nrf2, NF-kB) signal substances were analyzed. The results of analysis showed that the expression of inflammatory cells caused by gastric bleeding was significantly lowered in the berchemia berchemiifolia extract administration groups, and the expression of inflammatory proteins showed a similar tendency. Therefore, berchemia berchemiifolia extract is expected to become a candidate substance for new drugs and health foods for the treatment of gastritis and gastric ulcer.
Authors and Affiliations
Byung-Moon Jin1, Hae-Gyung Yoon, Gil-Hyun Lee3, , Kyung-Yae Hyun3*
Keywords
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- EP ID EP386744
- DOI 10.9790/3008-1106015964
- Views 69
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