BIOLOGICAL STUDIES ON NITROGEN - CONTAINING COMPOUNDS FROM CAMPYLOSPERMUM OLIVERIANUM AND CAMPYLOSPERMUM SULCATUM (OCHNACEAE)
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: Campylospermum oliverianum and C. sulcatum (Ochnaceae) are considered conspecific by some reports.Methods: Following phytochemical analyses on those species, biological tests were carried.Results: Phytotchemical analyses led to the isolation of three known nitrogenous compounds: two cyanoglucosides named dhurrin and menisdaurin and an indole alkaloid, serotobenine. These nitrogen-containing compounds showed potent cytotoxic activities against the microcrustacean Artemia salina (brine shrimp), when two of them exhibited efficient bactericidal effects against a few Gram cocci. This newest co-occurrence of both α- and γ-hydroxynitrile glucosides within the same species suggested another biosynthetic pathway for putative tyrosine-derived non-cyanogenic cyanoglucosides.Conclusion: This study does not recommend an identical chemical profile for the two species, hence they might not be regarded as the same. The biosynthetic pathway of numerous putative tyrosine-derived cyanoglucosides is supported by the isolated compounds from C. sulcatum. The taxonomical value of serotobenine in species of the Campylospermum genus as well as the other one of cyanoglucosides in angiosperms is once more highlighted.Â
Authors and Affiliations
Auguste Abouem A Zintchem, Joseph Thierry Ndongo, Serge Dominique Ngono Bikobo, Jeanne Louise Nkot
Keywords
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