IN-VITRO DISSOLUTION STUDY OF MELOXICAM IMMEDIATE RELEASE PRODUCTS USING FLOW THROUGH CELL (USP APPARATUS 4) UNDER DIFFERENT OPERATIONAL CONDITIONS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: To evaluate and compare the in-vitro dissolution profiles of five generic immediate release (IR) products of Meloxicam (MX) available in Egyptian market with the innovator reference product (Mobic®, R) using different operational conditions of the flow through dissolution cell (FTC, USP Apparatus 4), in phosphate buffer (pH=7.5).Methods: The comparative in-vitro dissolution studies were performed under different FTC operational conditions such as cell size, tablet position within the cell, open and closed loops setup and type of flow (laminar and turbulent) on MX dissolution rate from different IR products.Results: The study showed that two generic products, out of five, gave similar dissolution profiles with R using a specified well controlled condition of FTC. A selected generic product (Mobitil, G1) was tested versus R under different operational conditions of the FTC such as cell size, type of flow, tablet position and open & closed loops setup. The dissolution profile of MX from R was highly affected by changing the tablet position, slightly affected by the open & closed loops setup and not affected by cell size and type of flow. On the other hand, the dissolution profile of MX from G1 was affected by all the previous operational conditions. Comparing Æ’2 values between G1 against R among the different operational conditions proposed, only one in-vitro dissolution test showed similar dissolution profile of G1 with respect to R.Conclusion: Three generic products of MX might not be interchangeable with the innovator product (Mobic®).Â
Authors and Affiliations
Laila Hassanien Emara, Maha Fawzi Emam, Nesrin Foad Taha, Ahmed Abd El-rahman El-ashmawy, Nadia Mohamed Mursi
Keywords
Related Articles
- EP ID EP579300
- DOI -
- Views 79
- Downloads 0
A CASE OF HYPOTHYROIDISM INDUCED RECURRENT DEPRESSIVE DISORDER
Recurrent depressive disorder is a lifelong illness with relapses and remissions. The aetiology is biopsychosocial, genetic factors contributing and life stressors exaggerating the disease. Due to recurrent episodes the...
MICROBIOLOGICAL STUDY OF ORAL FLORA IN DIABETIC PATIENTS WITH GINGIVITIS
Objective: Given the importance of the association between diabetes and periodontal disease, the main objective of the present study was to compare the microbial diversity responsible for gingivitis in patients with and...
ANTIDYSLIPIDEMIC ACTIVITY OF KATUK LEAVES SAPONINS FRACTION (SAUROPUS ANDROGYNUS (L.) MERR) IN RATS INDUCED WITH FAT-RICH DIET
Objective: The present study was to evaluate the anti dyslipidemic activity and the atherogenic indicator of saponin compound from katuk leaves (Sauropus androgynus (L).Methods: This compound separated from Katuk leaves...
EVALUATION OF DEPEGMENTING AND ANTIERYTHEMIC EFFECTS OF COSMETIC EMULGELS CONTAINING RASPBERRY FRUIT EXTRACT ON HUMAN CHEEK SKIN
Objective: This research work was performed to discover the efficacy of newly formulated topical formulation (o/w) emulgel of Raspberry fruit extract against its base taken as a control on skin erythema and skin melanin....
MICROWAVE IRRADIATED “GREEN BIGINELLI REACTION†EMPLOYING APPLE, POMEGRANATE AND GRAPE JUICE AS ECO-FRIENDLY REACTION MEDIUM
Objective: The main objective of this work is to explore the utility of apple, pomegranate and grape juice as an eco-friendly reaction medium for microwave assisted green Biginelli reaction.Methods: A series of Biginelli...