MICROWAVE IRRADIATED “GREEN BIGINELLI REACTION†EMPLOYING APPLE, POMEGRANATE AND GRAPE JUICE AS ECO-FRIENDLY REACTION MEDIUM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
Objective: The main objective of this work is to explore the utility of apple, pomegranate and grape juice as an eco-friendly reaction medium for microwave assisted green Biginelli reaction.Methods: A series of Biginelli reactions were carried out in various fruit juice medium by employing an equimolar mixture of urea, ethyl acetoacetate and aromatic aldehyde as reactants. All the reactions were performed with the help of microwave irradiation. After successful completion of the reactions, the crude products were isolated, and the pure products were obtained after recrystallization of the crude product from hot ethanol.Results: It was worth to note that all the reactions were completed successfully within few minutes of duration. Pure apple, pomegranate and grape juices were proved to be fruitful as eco-friendly reaction medium for performing microwave-assisted green Biginelli reaction.Conclusion: A green, eco-friendly and cost-effective method was developed for microwave assisted “green Biginelli reaction†in apple, pomegranate and grape juice medium. This new method will further motivate the researchers to use more of common fruit juices instead of toxic solvents as reaction medium for multi-component condensation reactions.Keywords: Green synthesis, Fruit Juice, Biginelli reaction, Microwave
Authors and Affiliations
Tanay Pramanik, Simarjit Kaur Padan
Keywords
Related Articles
- EP ID EP577828
- DOI -
- Views 44
- Downloads 0
FREE RADICAL LOAD IN LYMPHOID ORGANS (SPLEEN AND THYMUS) OF INDIAN GOAT CAPRA HIRCUS: ROLE OF SEX, SEASON AND MELATONIN
Objective: Lymphoid organs (i.e. spleen and thymus) are important due to functional dynamicity. As a result, the generated free radicals may limit their function. Thus, present study was aimed to note seasonal and sex de...
DEVELOPMENT OPTIMIZATION AND EVALUATION OF EFFERVESCENT TABLETS OF CHLORPHENIRAMINE MALEATE USING BOX BEHNKEN DESIGN
Objective: The objective of present study was to develop effervescent tablets of Chlorpheniramine maleate (CPM) for the treatment of dysphasia.Methods: Effervescent tablets were prepared by direct compression method and...
PREPARATION OF PLANT MUCILAGE CLARIFICANTS AND THEIR EFFECT ON JAGGERY PROCESSING OF SUGARCANE VARIETY Co 86032
Objective: The aim of the study was to prepare jaggery from sugarcane variety Co86032 using plants mucilage as clarificants and to determine the effect of plant mucilage on jaggery processing.Methods: Production of jagge...
A GLOBAL COMPARISON AND ANALYSIS OF NEURAMINIDASE H1N1 STRAIN OF INFLUENZA A
Objective: To evaluate the variation of neuraminidase (NA) protein from various H1N1 strain for drug designing.Methods: In this study we have used 12 sequences of NA protein from various countries, retrieved from Uniprot...
EVALUATION HYPOLIPIDEMIC ACTIVITY OF AROGYAVARDHINI AND ZPTER TABLET IN CHOLESTEROL-RICH HIGH FAT DIET (HFD) INDUCED HYPERLIPIDEMIA IN WISTAR RATS
Objective: The present research work aims to evaluate the hypolipidemic activity of arogyavardhini and zpter tablet in high fat diet (HFD) induced hyperlipidemia in wistar rats. Methods: Wistar rats were divided in 5 gr...