DETERMINATION OF INDONESIAN NATIVE STINGLESS BEE PROPOLIS AS COMPLEMENTARY NUTRACEUTICAL CANDIDATE OF ANTI-TUBERCULOSIS DRUG

Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 4

Abstract

Objective: This study aimed to determine Indonesian native stingless bee propolis from ten provinces of Indonesia as complementary nutraceutical candidate of anti-tuberculosis drug (ATD).Methods: Propolis samples were collected from stingless bee cultivated in ten provinces of Indonesia. The antioxidant capacity test was performed using 2,2-diphenyl-1-picrylhydrazyl and toxicity test was done using Brine Shrimp Lethality Test. The inhibition test of Mycobacterium tuberculosis (Mtb) was performed using Lowenstein-Jensen medium and bacterial colonies were estimated using Most Probable Number.Results: The highest antioxidant capacity was found in Geniotrigona incisa (G. incisa) propolis from South Sulawesi Province with an IC50of 100.05 ppm, while the lowest antioxidant capacity was found in Tetragonula minangkabau propolis from North Sumatera Province with an IC50 of 1378.90 ppm. The lowest propolis toxicity was found in Geniotrigona thorasica propolis from South Kalimantan Province with an LC50of >1000.00, while the highest propolis toxicity was found in Tetragonula laeviceps (T. laeviceps) propolis from Banten Province with an LC50 of<50.00. T. laeviceps propolis from Banten Province had the lowest Mtb inhibition, with the inhibition value of 1.59%. On the other hand, the highest inhibition was shown by Tetragonula biroi propolis from South Sulawesi Province and Tetragonula fuscobalteata propolis from West Nusa Tenggara Province with 100% inhibition value (equivalent to rifampicin).Conclusion: Based on all determinant parameters, G. incisa propolis from South Sulawesi Province has the highest score, and it is defined as complementary nutraceutical candidate of ATD.

Authors and Affiliations

Mahani . , A. Sulaeman, F. Anwar, M. R. m. Damanik, Hardinsyah .

Keywords

Related Articles

IMPLEMENTING SUSTAINABLE ERGONOMICS FOR POWER-LOOM TEXTILE WORKERS

Objective: This ergonomic study focuses on identifying and understanding the occupational health and safety risk aspects of power-loom industry workers from Solapur City, Maharashtra, India.Methods: The samples of 540 wo...

EVALUATION OF ANTI-OBESITY ACTIVITY OF SOLASODINE IN HIGH FAT DIET-INDUCED OBESITY IN RAT

Objective: This study was planned to study the anti-obesity activities of solasodine on high fat (HF) diet-induced obese rats.Methods: Wistar rats were divided into six groups. Control group (Group 1) received normal die...

ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF OLIVE TREE EXTRACT

Objective: The aim of this study was the in vivo evaluation of analgesic and anti-inflammatory effect of an olive tree extract with high polyphenols content.Methods: This olive tree extract was obtained from Moroccan oli...

ANTIBACTERIAL ACTIVITY OF SELECTED MEDICINAL PLANT IN TRADITIONAL TREATMENT OF WOUND INFECTION IN SOUTHEAST INDIA

Objective: The wound healing potential of fruit peel of Pithecellobium dulce Benth, a plant traditionally used for wound treatment against wound- infecting bacteria, was assessed using disc diffusion and microtitre plate...

BENEFICIAL EFFECTS OF COFFEE AND MAINTENANCE OF URIC ACID LEVELS

Objective: This study aimed in finding out if drinking coffee over a long term showed a marked influence on the serum uric acid level and Fasting blood glucose level.Methods: The study population had 200 healthy subjects...

Download PDF file
  • EP ID EP567516
  • DOI 10.22159/ijpps.2018v10i4.23850
  • Views 85
  • Downloads 0

How To Cite

Mahani . , A. Sulaeman, F. Anwar, M. R. m. Damanik, Hardinsyah . (2018). DETERMINATION OF INDONESIAN NATIVE STINGLESS BEE PROPOLIS AS COMPLEMENTARY NUTRACEUTICAL CANDIDATE OF ANTI-TUBERCULOSIS DRUG. International Journal of Pharmacy and Pharmaceutical Sciences, 10(4), 15-21. https://europub.co.uk/articles/-A-567516