Biomarkers, metabonomics, and drug development: Can inborn errors of metabolism help in understanding drug toxicity?

Journal Title: The AAPS Journal - Year 2007, Vol 9, Issue 3

Abstract

Application of “omics” technology during drug discovery and development is rapidly evolving. This review evaluates the current status and future role of “metabonomics” as a tool in the drug development process to reduce the safety-related attrition rates and bridge the gaps between preclinical and clinical, and clinical and market. Particularly, the review looks at the knowledge gap between the pharmaceutical industry and pediatric hospitals, where metabonomics has been successfully applied to screen and treat newborn babies with inborn errors of metabolism. An attempt has been made to relate the clinical pathology associated with inborn errors of metabolism with those of drug-induced pathology. It is proposed that extending the metabonomic biomarkers used in pediatric hospitals, as “advanced clinical chemistry” for preclinical and clinical drug development, is immediately warranted for better safety assessment of drug candidates. The latest advances in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy should help replace the traditional approaches of laboratory clinical chemistry and move the safety evaluation of drug candidates into the new millennium.

Authors and Affiliations

Subrahmanyam Vangala, Alfred Tonelli

Keywords

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  • EP ID EP681599
  • DOI  10.1208/aapsj0903031
  • Views 101
  • Downloads 0

How To Cite

Subrahmanyam Vangala, Alfred Tonelli (2007). Biomarkers, metabonomics, and drug development: Can inborn errors of metabolism help in understanding drug toxicity?. The AAPS Journal, 9(3), -. https://europub.co.uk/articles/-A-681599