Biophysical and Biochemical Markers of Skeletal Fluorosis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 3
Abstract
Abstract: Fluoride toxicity is a burgeoning problem in worldwide and also in Rajasthan, India. It may be serious problems in health of the adults and children. Several clinical and experimental studies have reported that the F induces bone deformities in skeletal fluorosis but mechanism of action is still unknown. In the present study, 55 male flurotic patients (age 33.9 ±8.1) were selected from the orthopaedic outdoor patient department at Nims Medical Hospital Jaipur India. The age matched controls (34.5±7.6) were selected from the area where fluoride content was less than 1.5 ppm. Tibial bowing, Saber Shin, bow-legs, Genu valgum, wider ends of long bones with other typical skeletal deformities and bone mineral density were examined to compare subjects and controls along with changes at diaphysis and metaphyses with calcification and ossification of ligaments. The serum biochemical marker namely alkaline phosphatase (ALP), hydroxyproline, vitamin D, calcium and phosphate were also measured. Results of the present study demonstrate presence of high phosphorus, ALP, hydroxyproline and reduced concentration of 25 Hydroxy Vitamin D and calcium among the fluorotic patients. On the basis of results it may conclude that different biochemical parameters provides a reliable indicator for monitoring the health status of the high endemic area of fluoride which are at risk of fluorosis. Keywords: Fluorosis, Biochemical Markers, Bone deformities
Authors and Affiliations
Mukesh Tiwari, Neena Tiwari, Varun Singh, Hemant chaturvedi
Keywords
Related Articles
- EP ID EP374763
- DOI -
- Views 73
- Downloads 0
A Comparative Study of Second Trimester Termination of Pregnancy with Mifepristone and Misoprostol Vs Misoprostol Alone
The aim is to study the efficacy and safety of combined Mifepristone and misoprostol used in second trimester abortions (>12 and up to 20 weeks) in comparison with only vaginal misoprostol. This study was conducted in th...
Study of anatomic position of Pterion in dry human skulls in Karnataka
Pterion is H-shaped sutural junction wherein the frontal and parietal bones superiorly, greater wing of sphenoid and squamous temporal inferiorly of one side meet. It is an important neurosurgical and anthropometric land...
Smoking Index and Auditory Reaction Time- A Comparative Study
Abstract:Tobacco smoking is known as one of the most abused drugs for all ages. Cigarette is a factor affecting reaction time due to stimulant property of its active ingredient nicotine. Smoking can be assessed by smokin...
Quantitative and Qualitative Assessment of Phenomenology of OCD at Saraswathi Institute of Medical Sciences, Hapur
Abstract: The study was performed from January 2017 to May 2018 Outdoor & Indoor patient, Department of psychiatry, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh, The study had 50 patients of OCD, 50 car...
Study of oxidative stress and hsCRP in alcoholic and nonalcoholic fatty liver disorders
Abstract: Alcoholic and nonalcoholic fatty liver disease is a very common global problem, in worldwide. During oxidative stress the pathological changes observed in AFLD and NAFLD. High CRP levels may put the patients, a...