Biostatistical Analysis on Medicinal Plant Toxicity
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 18, Issue 5
Abstract
Introduction/Aim: The incidences of medicinal plant toxicity in the society are becoming serious in the society. There is the need for scientist to determine the toxicity profile of most is therefore very important. Terminalia Chebula is traditionally is found in natural colon cleansers and used in treatment of constipation, digestive disorders, irregular fevers, flatulence, ulcers, vomiting, colic, and hemorrhoids. In this study the effect of sub-acute administration of Terminalia Chebula on the brain, spleen, and stomach were evaluated. Method: Rats of either sex were selected. Group 1 received distilled water (10 ml/ kg), while group 2, 3 and 4 received Terminalia Chebula 200, 400 and 800 mg/kg respectively. Animals were kept in standard cages and given access to the extract, water and food orally for 28 days, after which they were weighed and sacrificed. Blood was collected by cardiac puncture and taken immediately for hematological and chemo pathological analysis. The brain, spleen, and stomach were also harvested for histological study of the effect of the plant using Haematotoxylin and Eosin (H&E) staining technique. Result: There was Significant (P<0.05) decrease in RBC, HGB, MCV, while there was no change in the level of neutrophiles, basophiles, eosinophiles and platelets. The size of the brain, spleen and stomach were observed to be slightly significantly (p<0.05) increased in rats with dose level of 400 mg/kg, while there was no significant (p<0.05) change observed at the 200 and 800 mg/kg dose. Histopathological examination of the brain and stomach showed normal features at all doses. The spleen showed Slight lymphocyte hyperplasia at all doses and normal features at the control (10 ml/kg). Conclusion: result of the study suggests that care should be observed when taken this herb.
Authors and Affiliations
Bin Zhao, Xia Jiang, Jinming Cao, Kuiyun Huang
Keywords
Related Articles
- EP ID EP621875
- DOI 10.26717/BJSTR.2019.18.003212
- Views 169
- Downloads 0
Trifluoroacetic Acid-Promoted Friedel-Crafts Aromatic Alkylation with Benzyl Alcohols
Following the 1945 report by Newman on the utility of Trifluoroacetic Acid (TFA) as a condensing agent for the acylation of anisole with acetic anhydride [1], TFA has found enormous utility in organic synthesis [1-3]. Fo...
A Pedagogical Description of Channel Interference in Multiphoton Absorption Processes
In this mini-review, the author discusses a different view of two-photon absorption and in general any multi-photon absorption process in a molecular system in a very didactic way. This novel point of view is termed as "...
Reactive Oxygen Species Over Production and Superoxide Dismutase Exhaustion Promoting the Intervertebral Disc Degeneration
Background: Oxidative overstress is realized as one of the most prevalent causes of Intervertebral Disc Degeneration (IVDD) by restraining the metabolism and damaging the cell matrix, but the specific process i...
Cancer Cells Hijack the Genome of other Cell via Extracellular Vesicles
Nuclear Receptors are a superfamily of transcription factors that exhibit multiplefunctions in health anddisease [1]. These receptors play essential roles in various physiological processes; including metabolism, immunit...
Challenges in the treatment of West syndrome
West syndrome is a rare and severe infant epileptic encephalopathy, covering 25-30% of infantile epilepsies. It’s incidence is 2-3.5/ 10000 live births. The clinical picture usually starts with infantile spasms, which ca...