Biphasic Roles of a Small G-Protein, RAC1 in Pancreatic Β-Cell
Journal Title: Gastro - Open Journal - Year 2015, Vol 1, Issue 3
Abstract
Glucose-stimulated insulin secretion (GSIS) involves cross talk between small Gproteins and their regulating factors. These interactions results in translocation of insulin-laden granules to the plasma membrane for fusion and insulin release. Vesicular transport and fusion events are tightly regulated by signals which coordinate between vesicle- and membrane-associated docking proteins. It is now being accepted that small G-protein, Rac1-mediated Reactive Oxygen Species (ROS) functions as a second messenger in islet β-cell function. Further, evidence from multiple laboratories suggests a tonic increase in ROS generation is necessary for GSIS and fatty acid-induced insulin secretion. On the other hand, Rac1-mediated NADPH oxidase-activation and subsequent generation of excessive ROS under glucolipotoxic conditions and cytokines exposure has proven to be detrimental for islet β-cell function. In this review we overview the normal physiological effects (positive role) and adverse effects (negative role) of activated small G-protein, Rac1 in pancreatic β-cells.
Authors and Affiliations
Ismail Syed
Keywords
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- EP ID EP555896
- DOI 10.17140/GOJ-1-114
- Views 147
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