Bis-Schiff Bases of Isatins: A New Class of Antioxidant
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Twenty seven (27) derivatives of bis-Schiff bases of isatins 1-27 were screened for their antioxidant potential. Out of twenty seven (27), four compounds exhibited a varying degree of superoxide anion radical scavenging activity with IC 50 values ranging between 156.34 - 273.15 µM. Compounds 7 ( IC 50 = 156.34 ± 0.22 µM), 9 ( IC 50 = 273.15 ± 1.60 µM), 13 ( IC 50 = 224.12 ± 0.80 µM), and 16 ( IC 50 = 225.03 ± 0.73 µM) showed a good superoxide anion radical scavenging activity, when compared to standard n-propyl gallate (IC 50 = 104.04 ± 1.70 µM). However, compounds 3 and 7 exhibited DPPH radical scavenging activity with IC 50 values 436.90 ± 0.59, 46.63 ± 0.26 µM, respectively.
Authors and Affiliations
Khal id Mohammed Khan, a Momi n Kh a n , a Ni d a Amb r e e n , a F a z a l Ra h im, a Bakht iar Muhammad, c S a j j
Keywords
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