minipellets for bacterial bone infections using precipitation technique: preparation, characterization and in-vitro antibiotic release studies
Journal Title: Journal of Pharmacy Research - Year 2010, Vol 3, Issue 1
Abstract
The present study concerns the preparation, characterization and in-vitro antibiotic release studies of various hydroxyapatite (HAp)-antibiotic implantable minipellets for bacterial bone infections like osteomyelitis. Various antibiotics like ciprofloxacin, ofloxacin, gatifloxacin and amoxicillin were loaded into HAp-system by precipitation technique. The significantly high drug loading was investigated in case of ciprofloxacin (64.14 ± 0.99 % w/w) in comparison of others as we followed the same process parameters. Various HAp-antibiotic minipellets were prepared by compressing synthesized HAp-antibiotic powders. Characterization of this drug delivery was done by P-XRD and FT-IR spectroscopy. These minipellets showed sustained release of antibiotics for several weeks and the drug release patterns followed by Higuchi model. This methodology may prove effective to develop high drug loaded various HAp-antibiotic implantable bone-delivery systems, thereby facilitating individualized chemotherapy for local delivery in bacterial bone infections.
Authors and Affiliations
Nayak A. K. *, Bhattacharya A. and Sen K. K.
Keywords
Related Articles
- EP ID EP84682
- DOI -
- Views 185
- Downloads 0
GC-MS Study on Methanol extract of Pleurotus platypus and Pleurotus eous
Methanol extraction of Pleurotus platypus and Pleurotus eous were subjected to identification of phytochemical compounds by using Gas chromatography – Mass spectrum technique. These two organisms were extracted with met...
Bis-Schiff Bases of Isatins: A New Class of Antioxidant
Twenty seven (27) derivatives of bis-Schiff bases of isatins 1-27 were screened for their antioxidant potential. Out of twenty seven (27), four compounds exhibited a varying degree of superoxide anion radical scavenging...
Phytochemical investigation and acute toxicity study of Methanol extract of Bambusa vulgaris leaves
The present study was undertaken to investigate the phytoconstituents present in methanol extract of Bambusa vulgaris leaves and to evaluate the acute oral toxicity of leaf extract on swiss albino mice by acute toxic cla...
Chiral switches: A Review
Chiral drug are made up of molecule with the same chemical structure, but different three-dimensional arrangements. Modern manufacturing has enabled the development of products containing a single molecular arrangement....
Fabrication and antibacterial evaluation of Chitosan/Poly(vinyl Alcohol)/Methylcellulose ternary blend film
The present study explores the fabrication of chitosan/poly(vinyl alcohol)/methylcellulose films in view of their increasing applications as antimicrobial packaging, wound dressing and antibacterial materials. The antim...