Blends of poly(L-lactide) and poly(L-lactide-co-trimethylene carbonate) as promising materials for bone and cartilage tissue engineering
Journal Title: Engineering of Biomaterials / Inżynieria Biomateriałów - Year 2018, Vol 21, Issue 145
Abstract
The aim of this work was to evaluate the properties of polymer blends of poly(L-lactide) and poly(L-lactide- -co-trimethylene carbonate) 15/85 and to select two compositions to be used to prepare the materials for bone and cartilage tissue engineering. PLLA and PLLATMC as the polymers with significantly different mechanical properties could be used to prepare a wide range of polymer blends. They were investigated by ultimate tensile strength and Young modulus measurements. Considering similar mechanical properties to these types of human tissues PLLA:PLLATMC 80:20 and 30:70 blends have been chosen as appropriate materials for bone and cartilage engineering, respectively. The materials were examined by thermal analysis (thermogravimetry and differential scanning calorimetry), ATR-FTIR spectroscopy and surface analysis (roughness and contact angle measurements). Miscibility of two polymers was discussed. High thermal stability of the blends allow to process them by fused deposition modelling which is one of the most promising methods for the manufacturing of computationally designed scaffolds. Based on the results of thermal analysis at least partial miscibility of PLLA and PLLATMC in the examined blends is indicated. Detailed interpretation of ATR-FTIR spectra let to distinguish the polymers despite their structural similarities. Surface properties of the materials depend on the preparation method and on their form.
Authors and Affiliations
J. Marchewka
Keywords
Related Articles
- EP ID EP553978
- DOI -
- Views 50
- Downloads 0
Structure and morphology of whitlockite coating electrophoretically deposited on NiTi shape memory alloy
In order to improve the biocompatibility of NiTi shape memory alloy, the surface was modified by formation of multifunctional layer consisted of titanium oxides and whitlockite ceramic. Amorphous TiO2 interlayer was prod...
Tribological properties of resorbable polylactide-based biomaterials
The objective of this study was the observation and evaluation of tribological characteristics and behavior of biocomposites with polymer matrix under different friction conditions. Three types of polylactide composites...
Surface functionalization of poly(L-lactide-co-glycolide) membranes with amphiphilic poly(2-oxazoline) for guided tissue regeneration and treatment of bone tissue defects
The main challenge of this research was to functionalize the surface of poly(L-lactide-co-glycolide) (PLGA) membranes with amphiphilic poly(2-oxazoline) (POx) in order to change PLGA chemical state and properties. Poly(2...
Interactions of carbon nanoparticles from packagings with components of food, drugs and biologically active molecules - a review
Nanomaterials are very important in the field of packaging of food, medicines and dietary supplements. Modern packagings often contain nanoparticles that provide them new feature - nanoparticles are used to activate main...
Modeling computational studies of modified drug molecules binding to the LRRK2 protein in the treatment of Parkinson’s disease
Parkinson’s disease is a neurodegenerative and progressive disease of the central nervous system. It affects more than 10 million patients worldwide and the symptoms allow for little to no control for movement. These sym...