Blood Coagulation Tests and Platelets Counts in Diabetic Rats Treated with Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata Leaf Extracts
Journal Title: International Blood Research & Reviews - Year 2015, Vol 3, Issue 1
Abstract
Aim: This study was designed to study the effects of leaves extracts of four indigenous Nigerian medicinal plants namely- Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata on platelets counts and blood coagulation tests (bleeding and clotting times) in alloxan induced diabetic rats with a view to further assess their safety in the management of diabetes mellitus. Design: Animal experiments were carried out on whole animals in the Physiology Laboratory of the College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria. Methodology: Forty five diabetic rats were divided into 9 groups of 5 rats each (groups 2-9), while group 1 comprised of 5 normal rats. Treatment was assigned to each group with a specified extract and dosed. At the end of treatment period bleeding and clotting times as well as platelets counts was determined for each animal. Results: All doses of the extracts significantly (P<.05) lowered the observed elevated platelets counts in the diabetic rats with 150 mg/kg of Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata lowering elevated platelets by 48.50, 47.26, 62.15 and 32.54% respectively. Same dose increased bleeding time by 460.6, 431.8, 430.3 and 213% respectively. Clotting time was also raised by 86.8, 63.57, 48.06, and 43.41 respectively. Conclusion: The results show that the leaf extracts of Ficus sur, Jatropha tanjorensis, and Mucuna pruriens contain principles with anti-haemostatic and fibrinolytic and could be of value in the prevention of blood coagulation diseases often associated with diabetes mellitus but leaves that of Chromolaena odorata for further evaluation.
Authors and Affiliations
Ijioma Solomon Nnah
Keywords
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- EP ID EP242417
- DOI 10.9734/IBRR/2015/14602
- Views 155
- Downloads 0
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