[b] Determination of Mirtazapine using fast Sulphone BlackF as Chromogenic Reagent[/b]
Journal Title: International Journal of Research in Chemistry and Environment (IJRCE) - Year 2013, Vol 3, Issue 2
Abstract
[i] A simple and sensitive extractive visible spectrophotometric method for the assay of Mirtazapine in pure and pharmaceutical formulations based on the formation of colored chloroform soluble ion-association associate under specified experimental conditions was described. The dye namely acidic dye Fast Sulphone Black F was utilized. The extract of the ion-associates exhibit absorption maxima at 520nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration range of 5-20μg/ml. The proposed method can be applied to commercial available formulations and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. The methods can be applied successfully for the estimation of the Mirtazapine in the presence of other ingredients that are usually present in formulations. The method offer the advantages of rapidity, simplicity and sensitivity and low cost without the need for expensive instrumentation and reagents. It is for the first time in the literature that an attempt is been made by the author to use FSBF is used as Chromogenic reagent.[/i]
Authors and Affiliations
Murthy Ch. V. R , Acharyulu M. L. N. , Reddy T. S , Srinivas B. V , Rao P. V. S. R. Mohana5
Keywords
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