Body Mass Index and Causal Relationships with Four Characteristic Female Cancers: A Two-Sample Mendelian Randomization Study
Journal Title: Global Academic Frontiers - Year 2024, Vol 2, Issue 1
Abstract
This study employs a two-sample Mendelian randomization (MR) approach to investigate the causal relationship between increased Body Mass Index (BMI) and four characteristic female cancers. BMI and data pertaining to the four characteristic female cancers were obtained from the GWAS database. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs) based on assumptions. The PhenoScanner method was utilized to eliminate SNPs associated with confounding factors. Five Mendelian randomization analysis methods, including inverse variance-weighted (IVW), were employed for two-sample Mendelian randomization analysis. Cochran Q and Rücker Q heterogeneity tests were conducted using IVW and MR-Egger methods. Egger-intercept method was employed for pleiotropy testing, and stepwise exclusion testing for sensitivity analysis. F-values were calculated to assess the presence of weak IVs bias. Genetically predicted increase in BMI was causally associated with reduced risk of breast cancer (OR=0.648, 95% CI: 0.535-0.783, P=7.74e-06), and increased risk of endometrial cancer (OR=1.534, 95% CI: 1.195-1.970, P=7.84e-04). There was insufficient evidence to suggest a causal relationship between genetically determined BMI increase and other characteristic female cancers studied. Increased Body Mass Index may potentially decrease the risk of female breast cancer while increasing the risk of endometrial cancer. There is inadequate evidence to indicate a significant impact of increased BMI on the occurrence risk of other characteristic female cancers studied. Further research is warranted to elucidate these findings.
Authors and Affiliations
Yulai YIN| Hebei Medical University,Xiaoyu ZHANG| Cangzhou Central Hospital
Keywords
Related Articles
- EP ID EP741416
- DOI -
- Views 24
- Downloads 0
Application and Research on Interface Design of Digital Government Operating System
As the first year of the digital economy, everything is undergoing earth shattering changes in 2023. With the rapid development of information technology, the digital economy is also gradually growing and expanding. As a...
Extraction of acid phosphatase from mung bean sprouts and determination of its enzymatic properties
To investigate the enzymatic properties of acid phosphatase from mung bean sprouts and explore the optimal reaction conditions for this enzyme. This study extracted phosphatase from fresh mung bean sprouts and determined...
Innovative Development of Vocational Education in Guangxi under the RCEP Framework
Within the RCEP framework, vocational education in Guangxi faces significant opportunities and challenges. This paper proposes strategies in three aspects: industry-education integration, faculty development, and interna...
Target enhancement interpretive processing techniques and their application in B area
The Ordovician reservoir in Area B is a carbonate fracture- controlled fractured-vuggy reservoir. The distribution of the reservoir is controlled by the slip fracture zones, with large differences in three-dimensional sp...
Enhancing Management Efficiency in Natural Parks Globally through Big Data Technologies
The adoption of big data technologies offers significant potential for enhancing the management efficiency of natural parks worldwide, a critical component in the establishment and upkeep of international conservation sy...