Abstract

Bone Marrow Necrosis (BMN) is an uncommon syndrome characterized by destruction of hematopoietic tissue with preservation of the bone. It presents as localized or diffuse generalized process. Many underlying diseases can lead to marrow necrosis: most commonly malignancies and rarely sickle cell disease. Although there are no clinical nor laboratory pathognomonic signs, clinicians must keep a high index of suspicion whenever there is fever, severe bone pain, elevated lactate dehydrogenase, and anemia. Bone marrow biopsy remains the mainstay of the diagnosis. BMN associated with sickle cell disease is usually of better prognosis compared to BMN secondary to malignancies.

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