Zika Induced Meningoencephalitis in a Ruxolitinib Treated Patient with Secondary Myelofibrosis
Journal Title: International Journal of Blood Research and Disorders - Year 2017, Vol 4, Issue 1
Abstract
We describe here the first case of a patient with post-ET myelofibrosis treated with ruxolitinib at French West Indies complicated with zika induced meningoencephalitis. Patient presented with fever, confusion along with conjunctivitis, diffuse joints pain and skin rash. PCR was positive for Zika virus in blood, urine and cerebrospinal fluid. Diagnosis of Zika induced meningoencephalitis was confirmed. The inhibition of the JAK/STAT receptor induced by ruxolitinib is implicated in inflammation and immune response and has been associated with several forms of viral complication. Patients under ruxolitinib should be considered at high risk of arboviruses complications in endemics areas.
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- EP ID EP350393
- DOI 10.23937/2469-5696/1410028
- Views 112
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