Bovine Disease-Related DNA Mutations and Their Genetic Control Strategies in Breeding for Disease Resistance
Journal Title: Genetic Disease Study - Year 2018, Vol 2, Issue 1
Abstract
Bovine genomic DNA mutations and their genetic effects on gene expression and protein function influence disease susceptibility and resistance of cattle. The genetic loci related to cattle diseases are mainly divided into two types: single-locus-disease genes and multigenic-disease loci. The single-locus-disease genes are called causal mutations; their genetic basis is simply and normally detected in the coding and non-coding regions inducing substitution of amino acid, premature termination of translation, and complete deletion of entire exon(s). In contrast, the genetic basis of disease related to multiple genes is more complex since susceptibility or resistance of these diseases is affected by the interactions among host, pathogen, and environment. This article reviewed current research and application of the major diseases of cattle con- trolled by single gene or polygenic genes. The genetic control strategies of effective identification and control of these dis- eases in bovine breeding and production were also analyzed.
Authors and Affiliations
Edward Nehemiah, Armand Kennan
Keywords
Related Articles
- EP ID EP679204
- DOI -
- Views 172
- Downloads 0
Advances in Gene Therapy for Human Genetic Diseases Based on Crispr/Cas9 Gene Editing Technology
The CRISPR/Cas9 system provides a powerful technique for targeted gene editing. Using sequence-specific sgRNA guidance, the CRISPR/Cas9 system can accurately introduce double-stranded incisions into the exact location of...
Automated Large-Scale Genome Scanning and Linkage Analysis Strategy of Genetic Disease Related Gene Location
With the development of the Human Genome Project, many methods have been applied in this field. Since the 1990s, large-scale scanning and mapping of base circles have been established and developed by combining linkage a...
Phylogeny of Human Mitochondrial DNA Lineages and Its Applications
With the special intention to introduce the most widely adopted phylogenetic analysis human mitochondrial DNA (mtDNA) studi,the history of the reconstruction of mt DNA phylogny was reviewed. And the applications of human...
Whole Genome Sequencing Progress in Medical Application
At present, there are still a lot of diseases pathogenesis not clear, but making use of a new generation of sequencing technology to organisms conduct whole genome sequencing, which for the pathogenesis of many diseases...
Bovine Disease-Related DNA Mutations and Their Genetic Control Strategies in Breeding for Disease Resistance
Bovine genomic DNA mutations and their genetic effects on gene expression and protein function influence disease susceptibility and resistance of cattle. The genetic loci related to cattle diseases are mainly divided int...